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- W162309764 abstract "Abstract Lymphocyte and TNF deficiency leads to susceptibility to opportunistic infections such as Pneumocystis carinii (PC). This strongly indicates that protection against the fungal pathogen PC is dependent upon B cells, T cells and TNF. Although it has been documented that macrophage derived TNF is essential for PC clearance, the role played by TNF produced by lymphocytes has not been addressed. Furthermore, the functional role of B cells in the T cell-mediated protection against PC Pneumonia (PCP) has not been determined. In this study we report that B cells produce TNF in response to PC predominantly in the TBLN. B cells enhanced expansion of CD4 T cells and secretion of TNF in the lungs of adoptive transfer recipients and hence clearance of the organisms. Importantly, the presence of B cells resulted in upregulation of Bcl2 in CD4 T cells and down regulation of Fas and Fas Ligand consistent with a decrease in apoptotic cells as determined by annexin V staining. Lastly, we observed that T cell-derived TNF is critical for PC clearance. Taken together, our data suggest that B cells are essential for CD4 T cell survival and increased expansion leading to protection against PCP in mouse models." @default.
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- W162309764 date "2010-04-01" @default.
- W162309764 modified "2023-09-27" @default.
- W162309764 title "Elevated Bcl2 expression in mice decreases CD4 lymphocyte apoptosis and facilitates clearance of Pneumocystis in mice (40.6)" @default.
- W162309764 doi "https://doi.org/10.4049/jimmunol.184.supp.40.6" @default.
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