FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1623241421> ?p ?o ?g. }

• W1623241421 endingPage "491" @default.
• W1623241421 startingPage "491" @default.
• W1623241421 abstract "Sir,We read with interest the article by Shenoy and colleagues1 on blandm-1 gene in multidrug resistant (MDR) Gram-negative bacilli. In a country with 60-80 per cent prevalence of extended spectrum beta-lactamase (ESBL) among hospital Gram-negative isolates with co-resistance to other classes of antimicrobials as high as 44 per cent to co-trimoxazole, 76 per cent to gentamicin, 88 per cent to tetracycline and 90 per cent to fluoroquinolones, the authors’ report of only 1.48 per cent MDR Gram-negative bacilli in a tertiary care centre is surprising2,3. There are certain points which need to be clarified:The definition of MDR is very vague and without any reference in the article1. MDR, in literal terms means ‘resistant to more than one antimicrobial agent’, but a standardized definition for MDR has not yet been agreed upon by the medical community. There are many definitions that are currently being used to characterize patterns. The most practical definition used for Gram-positive and Gram-negative bacteria is ‘resistant to three or more antimicrobial classes’4. Selecting Gram-negative isolates resistant to 1st and 2nd line antibiotics by standard disk diffusion test was very difficult as isolates were from different sites which had different antibiotics in their 1st and 2nd line of treatment. It is important for the authors to clearly define their criteria for MDR Gram-negative isolates as they have reported a low percentage of MDR Gram-negative isolates, and also that 93.24 per cent of these were phenotypically MBL producers, which is very alarming.The authors did not define how the carbapenamase producers were initially screened. Only imipenem (IPM) was tested by disk diffusion method. So how did the authors determine “variable carbapenem resistance”?. It will be interesting to see what type of variable carbapenem resistance was seen. They also need to mention all the carbapenems tested in their study and their MIC (minimum inhibitory concentration) at least as generated by Vitek 2 Compact 60.What the authors have described in the Material & Methods section is combined-disk test, not the double disk synergy test (DDST). In the DDST, an IPM (10 µg) disk is placed 20 mm (center to center) from a blank disk containing 10 µl of 0.1 M (292 µg) EDTA. Enhancement of the zone of inhibition in the area between the two disks is considered positive for an MBL5.Table II: Denominators used for calculating percentages are misleading, e.g: while the table may be interpreted as 5.7 per cent of isolates of Acinetobacter baumannii were blandm-1 positive; the actual percentage is 20 per cent. The authors mentioned that 14.7 per cent of Escherichia coli isolates were NDM-1 positive in their study but the Table showed that 50 per cent (5/10) of the MDR E.coli were NDM-1 positive. We are unable to understand what the authors wish to convey through the current percentages in Table II? What does 115.38 per cent of tracheal aspirate mean; as well as 105 per cent of total isolates?Tigecycline resistant isolates need to be identified as Pseudomonas, Providencia and Burkholderia isolates are known to have higher MICs for tigecycline6." @default.
• W1623241421 created "2016-06-24" @default.
• W1623241421 creator A5052780255 @default.
• W1623241421 creator A5084934654 @default.
• W1623241421 date "2015-01-01" @default.
• W1623241421 modified "2023-10-16" @default.
• W1623241421 title "Defining multidrug resistance in Gram-negative bacilli" @default.
• W1623241421 cites W1500896087 @default.
• W1623241421 cites W1983269321 @default.
• W1623241421 cites W2107733324 @default.
• W1623241421 cites W2142343447 @default.
• W1623241421 cites W2151545489 @default.
• W1623241421 cites W76974362 @default.
• W1623241421 doi "https://doi.org/10.4103/0971-5916.159318" @default.
• W1623241421 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4510737" @default.
• W1623241421 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26112856" @default.
• W1623241421 hasPublicationYear "2015" @default.
• W1623241421 type Work @default.
• W1623241421 sameAs 1623241421 @default.
• W1623241421 citedByCount "5" @default.
• W1623241421 countsByYear W16232414212020 @default.
• W1623241421 countsByYear W16232414212021 @default.
• W1623241421 countsByYear W16232414212022 @default.
• W1623241421 countsByYear W16232414212023 @default.
• W1623241421 crossrefType "journal-article" @default.
• W1623241421 hasAuthorship W1623241421A5052780255 @default.
• W1623241421 hasAuthorship W1623241421A5084934654 @default.
• W1623241421 hasBestOaLocation W16232414211 @default.
• W1623241421 hasConcept C104317684 @default.
• W1623241421 hasConcept C114851261 @default.
• W1623241421 hasConcept C133936738 @default.
• W1623241421 hasConcept C161369605 @default.
• W1623241421 hasConcept C2776051709 @default.
• W1623241421 hasConcept C2776870249 @default.
• W1623241421 hasConcept C523546767 @default.
• W1623241421 hasConcept C54355233 @default.
• W1623241421 hasConcept C547475151 @default.
• W1623241421 hasConcept C71924100 @default.
• W1623241421 hasConcept C86803240 @default.
• W1623241421 hasConcept C89423630 @default.
• W1623241421 hasConceptScore W1623241421C104317684 @default.
• W1623241421 hasConceptScore W1623241421C114851261 @default.
• W1623241421 hasConceptScore W1623241421C133936738 @default.
• W1623241421 hasConceptScore W1623241421C161369605 @default.
• W1623241421 hasConceptScore W1623241421C2776051709 @default.
• W1623241421 hasConceptScore W1623241421C2776870249 @default.
• W1623241421 hasConceptScore W1623241421C523546767 @default.
• W1623241421 hasConceptScore W1623241421C54355233 @default.
• W1623241421 hasConceptScore W1623241421C547475151 @default.
• W1623241421 hasConceptScore W1623241421C71924100 @default.
• W1623241421 hasConceptScore W1623241421C86803240 @default.
• W1623241421 hasConceptScore W1623241421C89423630 @default.
• W1623241421 hasIssue "4" @default.
• W1623241421 hasLocation W16232414211 @default.
• W1623241421 hasLocation W16232414212 @default.
• W1623241421 hasLocation W16232414213 @default.
• W1623241421 hasLocation W16232414214 @default.
• W1623241421 hasLocation W16232414215 @default.
• W1623241421 hasOpenAccess W1623241421 @default.
• W1623241421 hasPrimaryLocation W16232414211 @default.
• W1623241421 hasRelatedWork W1623241421 @default.
• W1623241421 hasRelatedWork W2032247226 @default.
• W1623241421 hasRelatedWork W2103517471 @default.
• W1623241421 hasRelatedWork W2366238272 @default.
• W1623241421 hasRelatedWork W2386257037 @default.
• W1623241421 hasRelatedWork W2981380438 @default.
• W1623241421 hasRelatedWork W2997072349 @default.
• W1623241421 hasRelatedWork W3132515655 @default.
• W1623241421 hasRelatedWork W4238494755 @default.
• W1623241421 hasRelatedWork W1950983802 @default.
• W1623241421 hasVolume "141" @default.
• W1623241421 isParatext "false" @default.
• W1623241421 isRetracted "false" @default.
• W1623241421 magId "1623241421" @default.
• W1623241421 workType "article" @default.