FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1623347898> ?p ?o ?g. }

• W1623347898 endingPage "425" @default.
• W1623347898 startingPage "419" @default.
• W1623347898 abstract "The ability of Coxiella burnetii to couple oxidation of metabolic substrates to adenosine 5′-triphosphate (ATP) synthesis in axenic reaction buffers was examined. Pyruvate, succinate, and glutamate were catabolized and incorporated at the highest rates of 11 substrates tested. Glutamate oxidation, however, resulted in the greatest stability of the ATP pool and highest intracellular ATP levels over a 48-h period. At pH 4.5, the optimum for metabolism by C. burnetii , glutamate oxidation resulted in maintenance of the ATP pool at a concentration of approximately 0.7 nmol of ATP per mg of dry weight over a 96-h period. In the absence of substrate, ATP declined by 96 h to less than 0.01 nmol/mg of dry weight. When cells were maintained at pH 7.0 in the presence or absence of glutamate, ATP pools were considerably more stable, presumably due to the minimal metabolic activity displayed by C. burnetii at pH 7. The stability of the ATP pool reflected viability as there was greater than an 8-log decrease in viable C. burnetii after incubation for 7 days at pH 4.5 in the absence of glutamate. Viability was retained in the presence of glutamate at pH 4.5 or 7.0 in the absence of any added substrate. The stability of the ATP pool was due to endogenous synthesis of ATP coupled to substrate oxidation as shown by depression of ATP levels in the presence of inhibitors of electron transport or oxidative phosphorylation. In addition, the adenylate energy charge increased from an initial value of 0.57 to 0.73 during glutamate oxidation with a concomitant rise in the total adenylate pool size. C. burnetii therefore appears able to regulate endogenous ATP levels in response to substrate availability and pH, thus effecting a conservation of metabolic energy in neutral or alkaline environments. Such a mechanism has been proposed to play a role in the resistance of C. burnetii to environmental conditions and subsequent activation upon entry into the phagolysosome in which this organism replicates." @default.
• W1623347898 created "2016-06-24" @default.
• W1623347898 creator A5014681113 @default.
• W1623347898 creator A5051283258 @default.
• W1623347898 date "1981-11-01" @default.
• W1623347898 modified "2023-09-27" @default.
• W1623347898 title "Stability of the Adenosine 5′-Triphosphate Pool in <i>Coxiella burnetii</i> : Influence of pH and Substrate" @default.
• W1623347898 cites W1504264471 @default.
• W1623347898 cites W1524920697 @default.
• W1623347898 cites W1833026587 @default.
• W1623347898 cites W1899626910 @default.
• W1623347898 cites W1915812727 @default.
• W1623347898 cites W1976924263 @default.
• W1623347898 cites W2014358885 @default.
• W1623347898 cites W2027954296 @default.
• W1623347898 cites W2063302324 @default.
• W1623347898 cites W2095487455 @default.
• W1623347898 cites W2100277358 @default.
• W1623347898 cites W2112258048 @default.
• W1623347898 cites W2136966421 @default.
• W1623347898 cites W2163224449 @default.
• W1623347898 cites W2168814896 @default.
• W1623347898 cites W2174269416 @default.
• W1623347898 cites W2409304727 @default.
• W1623347898 doi "https://doi.org/10.1128/jb.148.2.419-425.1981" @default.
• W1623347898 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/216222" @default.
• W1623347898 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6117546" @default.
• W1623347898 hasPublicationYear "1981" @default.
• W1623347898 type Work @default.
• W1623347898 sameAs 1623347898 @default.
• W1623347898 citedByCount "40" @default.
• W1623347898 countsByYear W16233478982012 @default.
• W1623347898 countsByYear W16233478982013 @default.
• W1623347898 countsByYear W16233478982014 @default.
• W1623347898 countsByYear W16233478982015 @default.
• W1623347898 countsByYear W16233478982016 @default.
• W1623347898 countsByYear W16233478982017 @default.
• W1623347898 countsByYear W16233478982019 @default.
• W1623347898 countsByYear W16233478982020 @default.
• W1623347898 countsByYear W16233478982021 @default.
• W1623347898 countsByYear W16233478982023 @default.
• W1623347898 crossrefType "journal-article" @default.
• W1623347898 hasAuthorship W1623347898A5014681113 @default.
• W1623347898 hasAuthorship W1623347898A5051283258 @default.
• W1623347898 hasBestOaLocation W16233478981 @default.
• W1623347898 hasConcept C100206155 @default.
• W1623347898 hasConcept C104317684 @default.
• W1623347898 hasConcept C112243037 @default.
• W1623347898 hasConcept C165135838 @default.
• W1623347898 hasConcept C171357686 @default.
• W1623347898 hasConcept C180526460 @default.
• W1623347898 hasConcept C181199279 @default.
• W1623347898 hasConcept C18903297 @default.
• W1623347898 hasConcept C25642318 @default.
• W1623347898 hasConcept C2776607032 @default.
• W1623347898 hasConcept C2777289219 @default.
• W1623347898 hasConcept C2779564974 @default.
• W1623347898 hasConcept C28859421 @default.
• W1623347898 hasConcept C2994266630 @default.
• W1623347898 hasConcept C3075310 @default.
• W1623347898 hasConcept C512185932 @default.
• W1623347898 hasConcept C55493867 @default.
• W1623347898 hasConcept C57600042 @default.
• W1623347898 hasConcept C62231903 @default.
• W1623347898 hasConcept C74539022 @default.
• W1623347898 hasConcept C86803240 @default.
• W1623347898 hasConcept C89423630 @default.
• W1623347898 hasConceptScore W1623347898C100206155 @default.
• W1623347898 hasConceptScore W1623347898C104317684 @default.
• W1623347898 hasConceptScore W1623347898C112243037 @default.
• W1623347898 hasConceptScore W1623347898C165135838 @default.
• W1623347898 hasConceptScore W1623347898C171357686 @default.
• W1623347898 hasConceptScore W1623347898C180526460 @default.
• W1623347898 hasConceptScore W1623347898C181199279 @default.
• W1623347898 hasConceptScore W1623347898C18903297 @default.
• W1623347898 hasConceptScore W1623347898C25642318 @default.
• W1623347898 hasConceptScore W1623347898C2776607032 @default.
• W1623347898 hasConceptScore W1623347898C2777289219 @default.
• W1623347898 hasConceptScore W1623347898C2779564974 @default.
• W1623347898 hasConceptScore W1623347898C28859421 @default.
• W1623347898 hasConceptScore W1623347898C2994266630 @default.
• W1623347898 hasConceptScore W1623347898C3075310 @default.
• W1623347898 hasConceptScore W1623347898C512185932 @default.
• W1623347898 hasConceptScore W1623347898C55493867 @default.
• W1623347898 hasConceptScore W1623347898C57600042 @default.
• W1623347898 hasConceptScore W1623347898C62231903 @default.
• W1623347898 hasConceptScore W1623347898C74539022 @default.
• W1623347898 hasConceptScore W1623347898C86803240 @default.
• W1623347898 hasConceptScore W1623347898C89423630 @default.
• W1623347898 hasIssue "2" @default.
• W1623347898 hasLocation W16233478981 @default.
• W1623347898 hasLocation W16233478982 @default.
• W1623347898 hasLocation W16233478983 @default.
• W1623347898 hasOpenAccess W1623347898 @default.
• W1623347898 hasPrimaryLocation W16233478981 @default.
• W1623347898 hasRelatedWork W1623347898 @default.
• W1623347898 hasRelatedWork W1930538767 @default.
• W1623347898 hasRelatedWork W2050444169 @default.

• next