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• W1623348971 abstract "Resveratrol (3,4',5-trihydroxy-trans-stilbene), a phytoalexin found in grape skins, peanuts, and red wine, has been reported to have a wide range of biological and pharmacological properties. Amyloid-β deposition and senile plaque-associated astrocytes are common neuropathological features of Alzheimer's disease. In this study, we have explored the effects of resveratrol on amyloid-β-peptide-mediated cytotoxicity in vitro and modulation of cell growth-regulatory gene products in astroglioma C6 cells to elucidate its possible mechanism for anti-cytotoxicity. Exposure of C6 cells to amyloid-β resulted in dose-dependent growth inhibition and morphological changes of C6 cells, which were recovered by pre-treatment with resveratrol. The anti-proliferative effect of amyloid-β was associated with the induction of tumor suppressor p53 and cyclin-dependent kinase (Cdk) inhibitor p21 (WAF1/CIP1) expression assessed by RT-PCR and Western blot analysis in time-dependent manner in C6 cells. In addition, the pro-apoptotic Bax expression was also up-regulated in amyloid-β-treated C6 cells without alteration of anti-apoptotic Bcl-2 and Bcl-XL expression. However, pre-treatment of resveratrol significantly inhibited amyloid-β-induced p53, p21 and Bax levels, suggesting that the modulation of p53, p21 and Bax levels could be one of the possible pathways by which resveratrol functions as anti-cytotoxic agent. Our results demonstrate that resveratrol may enhance the protection against amyloid-β-induced cytotoxicity by promoting the survival of glial cells." @default.
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• W1623348971 date "2005-04-01" @default.
• W1623348971 modified "2023-09-25" @default.
• W1623348971 title "Effect of Resveratrol on the Induction of Cdk Inhibitor p21 and Pro-apoptotic Bax Expression by amyloid-β in Astroglioma C6 Cells" @default.
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• W1623348971 doi "https://doi.org/10.5352/jls.2005.15.2.169" @default.
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