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• W1623405425 endingPage "3006" @default.
• W1623405425 startingPage "3002" @default.
• W1623405425 abstract "High avidity ligation of the TCR induces negative selection in the thymus and can also induce apoptosis of peripheral T cells. Costimulation through CD28 enhances T cell activation and facilitates negative selection in the thymus, but the role of CD28 in peripheral T cell deletional tolerance has not been investigated. We used 2C CD28 wild-type and 2C CD28-deficient strains to assess the effects of CD28 and TCR avidity on peripheral T cell expansion and apoptosis. We compared the activation, division, expansion, and apoptosis of CD28(+/+) and CD28(-/-) 2C cells in response to self-Ag (K(b)), alloantigens with intermediate (K(bm3)), high (L(d)), or very high (L(d) + QL9 peptide) avidity. With intermediate avidity alloantigen, the CD28 signal enhanced T cell activation and expansion. However, when T cells encountered high avidity alloantigen, the CD28 signal reduced T cell expansion and increased apoptosis. These results indicate that the CD28 signal can down-regulate peripheral T cell responses by increasing apoptosis when TCR ligation exceeds a critical threshold." @default.
• W1623405425 created "2016-06-24" @default.
• W1623405425 creator A5059063645 @default.
• W1623405425 creator A5059543999 @default.
• W1623405425 creator A5060783496 @default.
• W1623405425 date "2003-03-15" @default.
• W1623405425 modified "2023-10-03" @default.
• W1623405425 title "CD28 Signal Enhances Apoptosis of CD8 T Cells After Strong TCR Ligation" @default.
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• W1623405425 doi "https://doi.org/10.4049/jimmunol.170.6.3002" @default.
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