FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1623408657> ?p ?o ?g. }

• W1623408657 endingPage "159" @default.
• W1623408657 startingPage "150" @default.
• W1623408657 abstract "The pharmacological activity of SU11274 is primarily due to its inhibition of hepotocyte growth factor receptor (c-Met) kinase overexpression. In this study, we demonstrated that the pathway involved in SU11274-induced autophagy was presumably through inhibition of c-Met and its down-stream pathways, including phosphatidylinositol 3-kinases – Akt (PI3K–Akt) and the growth factor receptor bound protein-2 / son of sevenless – Ras – p38 MAPK (Grb2/SOS–Ras–p38) pathway. SU11274 time-dependently induced the generation of superoxide anion (O2•−) and hydrogen peroxide (H2O2). There is a negative feedback loop between reactive oxygen species (ROS) induction and SU11274. Then, we investigated the role of ROS in protecting cells against SU11274-induced autophagic cell death in A549 cells. O2•− and H2O2 generation activated c-Met–PI3K–Akt and c-Met–Grb2/SOS–Ras–p38 signaling pathways, which were suppressed by O2•− scavenger superoxide dismutase (SOD) and H2O2 scavenger catalase. In conclusion, O2•− and H2O2 evoked cell resistance to SU11274 via activating c-Met–PI3K–Akt and c-Met–Grb2/SOS–Ras–p38 pathways in A549 cells. SU11274 also induced ROS generation in Caenorhabditis elegans." @default.
• W1623408657 created "2016-06-24" @default.
• W1623408657 creator A5015928213 @default.
• W1623408657 creator A5022644338 @default.
• W1623408657 creator A5045272575 @default.
• W1623408657 creator A5046319640 @default.
• W1623408657 creator A5060002817 @default.
• W1623408657 creator A5091089849 @default.
• W1623408657 date "2012-01-01" @default.
• W1623408657 modified "2023-10-05" @default.
• W1623408657 title "Activated O2^|^bull;^|^minus; and H2O2 Mediated Cell Survival in SU11274-Treated Non-Small-Cell Lung Cancer A549 Cells via c-Met^|^ndash;PI3K^|^ndash;Akt and c-Met^|^ndash;Grb2/SOS^|^ndash;Ras^|^ndash;p38 Pathways" @default.
• W1623408657 cites W1604551367 @default.
• W1623408657 cites W1963490763 @default.
• W1623408657 cites W1963945928 @default.
• W1623408657 cites W1965259410 @default.
• W1623408657 cites W1966598736 @default.
• W1623408657 cites W1969496278 @default.
• W1623408657 cites W1978468151 @default.
• W1623408657 cites W1984009434 @default.
• W1623408657 cites W1984569116 @default.
• W1623408657 cites W1986722295 @default.
• W1623408657 cites W1988230895 @default.
• W1623408657 cites W1992108786 @default.
• W1623408657 cites W1994735462 @default.
• W1623408657 cites W1994785136 @default.
• W1623408657 cites W1995485603 @default.
• W1623408657 cites W2009184356 @default.
• W1623408657 cites W2024811210 @default.
• W1623408657 cites W2025364264 @default.
• W1623408657 cites W2025593998 @default.
• W1623408657 cites W2027263866 @default.
• W1623408657 cites W2044322173 @default.
• W1623408657 cites W2044657305 @default.
• W1623408657 cites W2045816625 @default.
• W1623408657 cites W2054673942 @default.
• W1623408657 cites W2056855485 @default.
• W1623408657 cites W2058160101 @default.
• W1623408657 cites W2062845561 @default.
• W1623408657 cites W2066009040 @default.
• W1623408657 cites W2067459715 @default.
• W1623408657 cites W2083239953 @default.
• W1623408657 cites W2084984023 @default.
• W1623408657 cites W2086240498 @default.
• W1623408657 cites W2088047746 @default.
• W1623408657 cites W2089491251 @default.
• W1623408657 cites W2093664986 @default.
• W1623408657 cites W2104810144 @default.
• W1623408657 cites W2109034822 @default.
• W1623408657 cites W2114130733 @default.
• W1623408657 cites W2115365418 @default.
• W1623408657 cites W2116216023 @default.
• W1623408657 cites W2138309116 @default.
• W1623408657 cites W2140270650 @default.
• W1623408657 cites W2163360776 @default.
• W1623408657 cites W2163798716 @default.
• W1623408657 cites W2166245904 @default.
• W1623408657 doi "https://doi.org/10.1254/jphs.12048fp" @default.
• W1623408657 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22673163" @default.
• W1623408657 hasPublicationYear "2012" @default.
• W1623408657 type Work @default.
• W1623408657 sameAs 1623408657 @default.
• W1623408657 citedByCount "22" @default.
• W1623408657 countsByYear W16234086572013 @default.
• W1623408657 countsByYear W16234086572014 @default.
• W1623408657 countsByYear W16234086572015 @default.
• W1623408657 countsByYear W16234086572016 @default.
• W1623408657 countsByYear W16234086572017 @default.
• W1623408657 countsByYear W16234086572018 @default.
• W1623408657 countsByYear W16234086572019 @default.
• W1623408657 countsByYear W16234086572020 @default.
• W1623408657 countsByYear W16234086572021 @default.
• W1623408657 countsByYear W16234086572022 @default.
• W1623408657 countsByYear W16234086572023 @default.
• W1623408657 crossrefType "journal-article" @default.
• W1623408657 hasAuthorship W1623408657A5015928213 @default.
• W1623408657 hasAuthorship W1623408657A5022644338 @default.
• W1623408657 hasAuthorship W1623408657A5045272575 @default.
• W1623408657 hasAuthorship W1623408657A5046319640 @default.
• W1623408657 hasAuthorship W1623408657A5060002817 @default.
• W1623408657 hasAuthorship W1623408657A5091089849 @default.
• W1623408657 hasBestOaLocation W16234086571 @default.
• W1623408657 hasConcept C185592680 @default.
• W1623408657 hasConcept C502942594 @default.
• W1623408657 hasConcept C62478195 @default.
• W1623408657 hasConcept C75217442 @default.
• W1623408657 hasConcept C86554907 @default.
• W1623408657 hasConcept C86803240 @default.
• W1623408657 hasConcept C95444343 @default.
• W1623408657 hasConceptScore W1623408657C185592680 @default.
• W1623408657 hasConceptScore W1623408657C502942594 @default.
• W1623408657 hasConceptScore W1623408657C62478195 @default.
• W1623408657 hasConceptScore W1623408657C75217442 @default.
• W1623408657 hasConceptScore W1623408657C86554907 @default.
• W1623408657 hasConceptScore W1623408657C86803240 @default.
• W1623408657 hasConceptScore W1623408657C95444343 @default.
• W1623408657 hasIssue "2" @default.
• W1623408657 hasLocation W16234086571 @default.
• W1623408657 hasLocation W16234086572 @default.

• next