Matches in SemOpenAlex for { <https://semopenalex.org/work/W162344875> ?p ?o ?g. }
- W162344875 endingPage "116" @default.
- W162344875 startingPage "103" @default.
- W162344875 abstract "The regulation of neuronal iron is necessary for the synthesis of iron containing cytochromes and to prevent damage from free radicals by iron-oxygen interactions. We have shown that transferrin receptors are elevated over the substantia nigra in the human and rat brain (Mash et al., 1990) and are depleted concomitantly with dopaminergic terminals in the MPTP-treated mouse striatum (Mash et al., 1991). Given the iron dependency for both synthetic and degradative enzyme activities, dopaminergic neurons may express transferrin receptors on their cell surface to facilitate the uptake of iron bound to transferrin. If the intracellular iron pool is regulated by receptor-mediated transferrin uptake, then an up-regulation of transferrin receptor number may play a role in the pathogenesis of nigral cell damage in Parkinson’s disease. Early in the disease process, surviving dopaminergic neurons may increase the number of transferrin receptors in order to meet the increased metabolic demand associated with compensatory changes in dopamine synthesis and turnover. The uptake of ferrotransferrin by dopaminergic neurons may result in a progressive elevation in the cellular iron load that exceeds the regulatory capacity for increased ferritin expression in the aging brain." @default.
- W162344875 created "2016-06-24" @default.
- W162344875 creator A5009037991 @default.
- W162344875 creator A5045218431 @default.
- W162344875 creator A5049219398 @default.
- W162344875 creator A5051068104 @default.
- W162344875 creator A5074151067 @default.
- W162344875 creator A5084723460 @default.
- W162344875 date "1993-01-01" @default.
- W162344875 modified "2023-09-27" @default.
- W162344875 title "Iron storage and transport markers in Parkinson’s disease and MPTP-treated mice" @default.
- W162344875 cites W1509409430 @default.
- W162344875 cites W1525935121 @default.
- W162344875 cites W1970156306 @default.
- W162344875 cites W1971522061 @default.
- W162344875 cites W1978117713 @default.
- W162344875 cites W1979243660 @default.
- W162344875 cites W1980069149 @default.
- W162344875 cites W1985613988 @default.
- W162344875 cites W1988967704 @default.
- W162344875 cites W1996903201 @default.
- W162344875 cites W2005953011 @default.
- W162344875 cites W2015125090 @default.
- W162344875 cites W2018080238 @default.
- W162344875 cites W2019048519 @default.
- W162344875 cites W2019687889 @default.
- W162344875 cites W2030388326 @default.
- W162344875 cites W2032958110 @default.
- W162344875 cites W2039403847 @default.
- W162344875 cites W2040545684 @default.
- W162344875 cites W2040781504 @default.
- W162344875 cites W2041257981 @default.
- W162344875 cites W2062331704 @default.
- W162344875 cites W2062609550 @default.
- W162344875 cites W2069471046 @default.
- W162344875 cites W2074653842 @default.
- W162344875 cites W2075584689 @default.
- W162344875 cites W2082975967 @default.
- W162344875 cites W2093960008 @default.
- W162344875 cites W2099446928 @default.
- W162344875 cites W2124836276 @default.
- W162344875 cites W2148211039 @default.
- W162344875 cites W2151856890 @default.
- W162344875 cites W2152054410 @default.
- W162344875 cites W2156259977 @default.
- W162344875 cites W2165824166 @default.
- W162344875 cites W2171047055 @default.
- W162344875 cites W2178105210 @default.
- W162344875 cites W2336893408 @default.
- W162344875 cites W4233246745 @default.
- W162344875 cites W2305687011 @default.
- W162344875 doi "https://doi.org/10.1007/978-3-7091-9322-8_9" @default.
- W162344875 hasPublicationYear "1993" @default.
- W162344875 type Work @default.
- W162344875 sameAs 162344875 @default.
- W162344875 citedByCount "5" @default.
- W162344875 countsByYear W1623448752012 @default.
- W162344875 countsByYear W1623448752014 @default.
- W162344875 countsByYear W1623448752015 @default.
- W162344875 crossrefType "book-chapter" @default.
- W162344875 hasAuthorship W162344875A5009037991 @default.
- W162344875 hasAuthorship W162344875A5045218431 @default.
- W162344875 hasAuthorship W162344875A5049219398 @default.
- W162344875 hasAuthorship W162344875A5051068104 @default.
- W162344875 hasAuthorship W162344875A5074151067 @default.
- W162344875 hasAuthorship W162344875A5084723460 @default.
- W162344875 hasConcept C126322002 @default.
- W162344875 hasConcept C134018914 @default.
- W162344875 hasConcept C137183658 @default.
- W162344875 hasConcept C170493617 @default.
- W162344875 hasConcept C185592680 @default.
- W162344875 hasConcept C22814914 @default.
- W162344875 hasConcept C2778319317 @default.
- W162344875 hasConcept C2778674702 @default.
- W162344875 hasConcept C2779134260 @default.
- W162344875 hasConcept C2779734285 @default.
- W162344875 hasConcept C2780062018 @default.
- W162344875 hasConcept C2780938664 @default.
- W162344875 hasConcept C32264632 @default.
- W162344875 hasConcept C513476851 @default.
- W162344875 hasConcept C55493867 @default.
- W162344875 hasConcept C71924100 @default.
- W162344875 hasConcept C86803240 @default.
- W162344875 hasConcept C95444343 @default.
- W162344875 hasConceptScore W162344875C126322002 @default.
- W162344875 hasConceptScore W162344875C134018914 @default.
- W162344875 hasConceptScore W162344875C137183658 @default.
- W162344875 hasConceptScore W162344875C170493617 @default.
- W162344875 hasConceptScore W162344875C185592680 @default.
- W162344875 hasConceptScore W162344875C22814914 @default.
- W162344875 hasConceptScore W162344875C2778319317 @default.
- W162344875 hasConceptScore W162344875C2778674702 @default.
- W162344875 hasConceptScore W162344875C2779134260 @default.
- W162344875 hasConceptScore W162344875C2779734285 @default.
- W162344875 hasConceptScore W162344875C2780062018 @default.
- W162344875 hasConceptScore W162344875C2780938664 @default.
- W162344875 hasConceptScore W162344875C32264632 @default.
- W162344875 hasConceptScore W162344875C513476851 @default.