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- W1623462287 abstract "This chapter discusses the principles of immunological tolerance and immunocyte receptor blockade. The problem of immunologic tolerance is examined from two perspectives. First, from the viewpoint of the susceptible thymus-derived (T) or bone marrow-derived (B) lymphoid cel, four possible ways of achieving insusceptibility to appropriate activation signals are outlined. These are clonal abortion, clonal deletion, receptor blockade, and activation blockade. Clonal abortion is the elimination by antigen of lymphocytes with specificity for a given antigen through contact with that antigen at some postulated early maturation phase, when receptors have just appeared at the cell surface. Clonal deletion implies a destruction of fully developed and competent immunocytes as an end result of the attachment of certain forms and amounts of antigen to their surface. Receptor blockade is the saturation of antigen receptors with antigenic molecules that are, for some reason, nonimmunogenic and which prevent the cell from being stimulated by immunogenic antigen. Activation blockade is a more general concept relating to any factor or influence that may alter the lymphocyte's reactivity to antigen. These four mechanisms should not be regarded as alternatives, but rather as complementary concepts. The second approach is to divide tolerance phenomena on the basis of the structural nature of the antigen causing them. A new phenomenon is also described in the chapter —that is, the reduction in antibody secretion rate caused by the attachment of highly multivalent antigen to the surface of an antibody-forming cell." @default.
- W1623462287 created "2016-06-24" @default.
- W1623462287 creator A5042027098 @default.
- W1623462287 date "1974-01-01" @default.
- W1623462287 modified "2023-10-09" @default.
- W1623462287 title "Principles of Immunological Tolerance and Immunocyte Receptor Blockade" @default.
- W1623462287 cites W1500646025 @default.
- W1623462287 cites W1582857831 @default.
- W1623462287 cites W1617064581 @default.
- W1623462287 cites W1648458767 @default.
- W1623462287 cites W1649773148 @default.
- W1623462287 cites W1652473508 @default.
- W1623462287 cites W167478525 @default.
- W1623462287 cites W1691896390 @default.
- W1623462287 cites W1718724226 @default.
- W1623462287 cites W1779894790 @default.
- W1623462287 cites W184370928 @default.
- W1623462287 cites W1935010865 @default.
- W1623462287 cites W1974211586 @default.
- W1623462287 cites W1978177677 @default.
- W1623462287 cites W1981649594 @default.
- W1623462287 cites W1991655565 @default.
- W1623462287 cites W1997337913 @default.
- W1623462287 cites W2005365416 @default.
- W1623462287 cites W2008821247 @default.
- W1623462287 cites W2015112711 @default.
- W1623462287 cites W2015811110 @default.
- W1623462287 cites W2018886740 @default.
- W1623462287 cites W2019821346 @default.
- W1623462287 cites W2025912925 @default.
- W1623462287 cites W2031576783 @default.
- W1623462287 cites W2032362174 @default.
- W1623462287 cites W2033919411 @default.
- W1623462287 cites W2037148374 @default.
- W1623462287 cites W2037195433 @default.
- W1623462287 cites W2037677965 @default.
- W1623462287 cites W2040345119 @default.
- W1623462287 cites W2040613162 @default.
- W1623462287 cites W2044390886 @default.
- W1623462287 cites W2045947421 @default.
- W1623462287 cites W2047254116 @default.
- W1623462287 cites W2049501288 @default.
- W1623462287 cites W2050051633 @default.
- W1623462287 cites W2051800496 @default.
- W1623462287 cites W2053759980 @default.
- W1623462287 cites W2055766827 @default.
- W1623462287 cites W2055977968 @default.
- W1623462287 cites W2059431924 @default.
- W1623462287 cites W2063143669 @default.
- W1623462287 cites W2063856745 @default.
- W1623462287 cites W2063999184 @default.
- W1623462287 cites W2067342754 @default.
- W1623462287 cites W2069319055 @default.
- W1623462287 cites W2072948401 @default.
- W1623462287 cites W2073361332 @default.
- W1623462287 cites W2077214070 @default.
- W1623462287 cites W2078777959 @default.
- W1623462287 cites W2079757266 @default.
- W1623462287 cites W2081387236 @default.
- W1623462287 cites W2083618194 @default.
- W1623462287 cites W2091330521 @default.
- W1623462287 cites W2106542606 @default.
- W1623462287 cites W2114628082 @default.
- W1623462287 cites W2118933551 @default.
- W1623462287 cites W2122266314 @default.
- W1623462287 cites W2123118134 @default.
- W1623462287 cites W2130218069 @default.
- W1623462287 cites W2132255277 @default.
- W1623462287 cites W2135037585 @default.
- W1623462287 cites W2142617173 @default.
- W1623462287 cites W2142911793 @default.
- W1623462287 cites W2144369363 @default.
- W1623462287 cites W2144816860 @default.
- W1623462287 cites W2161827425 @default.
- W1623462287 cites W2162379739 @default.
- W1623462287 cites W2169102863 @default.
- W1623462287 cites W2171804984 @default.
- W1623462287 cites W2177431540 @default.
- W1623462287 cites W294906880 @default.
- W1623462287 cites W4211039185 @default.
- W1623462287 cites W4238260514 @default.
- W1623462287 cites W4245824918 @default.
- W1623462287 cites W4313307104 @default.
- W1623462287 cites W4313307157 @default.
- W1623462287 cites W4313308872 @default.
- W1623462287 cites W4313387052 @default.
- W1623462287 cites W61020862 @default.
- W1623462287 cites W83384372 @default.
- W1623462287 doi "https://doi.org/10.1016/s0065-230x(08)60109-8" @default.
- W1623462287 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/4142364" @default.
- W1623462287 hasPublicationYear "1974" @default.
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