Matches in SemOpenAlex for { <https://semopenalex.org/work/W1623604188> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W1623604188 abstract "We have found that over one-half of the total cell surface 125I-insulin-like growth factor I (IGF-I) binding to BHK cells represents binding to IGF binding proteins (IGFBPs) rather than to the IGF-I receptor. In addition to a number of secreted IGFBPs, we have now characterized two cell-associated IGFBPs with unique characteristics. The cell-associated IGFBPs have molecular weights of 30,000 (30K) and 25,000 (25K), as determined by the Western ligand blot technique. IGFBP-30K is located at the cell surface and can be readily labeled by affinity cross-linking with 125I-IGF-I. Surface expression of IGFBP-30K increases 5.4 +/- 1.2-fold (n = 11) with serum starvation. This induction is fully evident by 4 h, plateauing by 24 h, and is completely inhibitable by cycloheximide. The fasting-induced increase in IGFBP-30K is inhibited by IGF-I and by des-IGF-I and, to a lesser extent, by insulin. Unlike cell-associated IGFBP-30K, secretion of IGFBP was stimulated (6.8 +/- 0.5-fold, n = 2) by IGF-I, whereas IGFBP secretion was inhibited 54% by insulin. These results demonstrate coordinate regulation of IGFBP by serum starvation and IGF-I, such that at low concentrations of IGF-I, cell surface binding protein increases whereas binding protein secretion decreases. At high concentrations of IGF-I, IGFBP secretion increases and cell surface IGF-I receptor, as well as IGFBP, decreases. Taken together, these regulatory events regulate the availability of IGF-I for biologic signalling." @default.
- W1623604188 created "2016-06-24" @default.
- W1623604188 creator A5023821870 @default.
- W1623604188 creator A5091832115 @default.
- W1623604188 date "1992-12-01" @default.
- W1623604188 modified "2023-09-29" @default.
- W1623604188 title "Characterization of insulin-like growth factor (IGF) binding proteins and their role in modulating IGF-I action in BHK cells." @default.
- W1623604188 cites W1602528313 @default.
- W1623604188 cites W1911366696 @default.
- W1623604188 cites W1959209906 @default.
- W1623604188 cites W1964203795 @default.
- W1623604188 cites W1972819401 @default.
- W1623604188 cites W1985220842 @default.
- W1623604188 cites W1992668278 @default.
- W1623604188 cites W2016557888 @default.
- W1623604188 cites W2018723236 @default.
- W1623604188 cites W2032558447 @default.
- W1623604188 cites W2034816153 @default.
- W1623604188 cites W2039244588 @default.
- W1623604188 cites W2043576320 @default.
- W1623604188 cites W2065089372 @default.
- W1623604188 cites W2071757792 @default.
- W1623604188 cites W2072826506 @default.
- W1623604188 cites W2131233538 @default.
- W1623604188 cites W2137289472 @default.
- W1623604188 doi "https://doi.org/10.1016/s0021-9258(19)74079-4" @default.
- W1623604188 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1281161" @default.
- W1623604188 hasPublicationYear "1992" @default.
- W1623604188 type Work @default.
- W1623604188 sameAs 1623604188 @default.
- W1623604188 citedByCount "21" @default.
- W1623604188 countsByYear W16236041882013 @default.
- W1623604188 countsByYear W16236041882021 @default.
- W1623604188 crossrefType "journal-article" @default.
- W1623604188 hasAuthorship W1623604188A5023821870 @default.
- W1623604188 hasAuthorship W1623604188A5091832115 @default.
- W1623604188 hasBestOaLocation W16236041881 @default.
- W1623604188 hasConcept C104317684 @default.
- W1623604188 hasConcept C126322002 @default.
- W1623604188 hasConcept C134018914 @default.
- W1623604188 hasConcept C1491633281 @default.
- W1623604188 hasConcept C153911025 @default.
- W1623604188 hasConcept C170493617 @default.
- W1623604188 hasConcept C2775960820 @default.
- W1623604188 hasConcept C2778128677 @default.
- W1623604188 hasConcept C2780378035 @default.
- W1623604188 hasConcept C2780689927 @default.
- W1623604188 hasConcept C3675279 @default.
- W1623604188 hasConcept C49039625 @default.
- W1623604188 hasConcept C553089730 @default.
- W1623604188 hasConcept C55493867 @default.
- W1623604188 hasConcept C62112901 @default.
- W1623604188 hasConcept C71924100 @default.
- W1623604188 hasConcept C80862487 @default.
- W1623604188 hasConcept C86803240 @default.
- W1623604188 hasConceptScore W1623604188C104317684 @default.
- W1623604188 hasConceptScore W1623604188C126322002 @default.
- W1623604188 hasConceptScore W1623604188C134018914 @default.
- W1623604188 hasConceptScore W1623604188C1491633281 @default.
- W1623604188 hasConceptScore W1623604188C153911025 @default.
- W1623604188 hasConceptScore W1623604188C170493617 @default.
- W1623604188 hasConceptScore W1623604188C2775960820 @default.
- W1623604188 hasConceptScore W1623604188C2778128677 @default.
- W1623604188 hasConceptScore W1623604188C2780378035 @default.
- W1623604188 hasConceptScore W1623604188C2780689927 @default.
- W1623604188 hasConceptScore W1623604188C3675279 @default.
- W1623604188 hasConceptScore W1623604188C49039625 @default.
- W1623604188 hasConceptScore W1623604188C553089730 @default.
- W1623604188 hasConceptScore W1623604188C55493867 @default.
- W1623604188 hasConceptScore W1623604188C62112901 @default.
- W1623604188 hasConceptScore W1623604188C71924100 @default.
- W1623604188 hasConceptScore W1623604188C80862487 @default.
- W1623604188 hasConceptScore W1623604188C86803240 @default.
- W1623604188 hasLocation W16236041881 @default.
- W1623604188 hasOpenAccess W1623604188 @default.
- W1623604188 hasPrimaryLocation W16236041881 @default.
- W1623604188 hasRelatedWork W1481362782 @default.
- W1623604188 hasRelatedWork W1532016378 @default.
- W1623604188 hasRelatedWork W1605635614 @default.
- W1623604188 hasRelatedWork W1959209906 @default.
- W1623604188 hasRelatedWork W1972393959 @default.
- W1623604188 hasRelatedWork W1975158342 @default.
- W1623604188 hasRelatedWork W1993807494 @default.
- W1623604188 hasRelatedWork W1996131974 @default.
- W1623604188 hasRelatedWork W2001166237 @default.
- W1623604188 hasRelatedWork W2002841462 @default.
- W1623604188 hasRelatedWork W2004377567 @default.
- W1623604188 hasRelatedWork W2020589003 @default.
- W1623604188 hasRelatedWork W2043576320 @default.
- W1623604188 hasRelatedWork W2061507924 @default.
- W1623604188 hasRelatedWork W2064350456 @default.
- W1623604188 hasRelatedWork W2105851758 @default.
- W1623604188 hasRelatedWork W2138675077 @default.
- W1623604188 hasRelatedWork W2154049094 @default.
- W1623604188 hasRelatedWork W2156100081 @default.
- W1623604188 hasRelatedWork W2417937027 @default.
- W1623604188 isParatext "false" @default.
- W1623604188 isRetracted "false" @default.
- W1623604188 magId "1623604188" @default.
- W1623604188 workType "article" @default.