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• W1624147664 abstract "Burger, Peter C. and Scheithauer, Bernd W. Tumors of the Central Nervous System (AFIP Atlas of Tumor Pathology, Series 4. Fascicle 7) American Registry of Pathology , Washington DC , 2007 . 596 + xiv Pages. Price $185 (hardback). ISBN- 1-933477-01-6 The new series of the AFIP Atlas of Tumor Pathology is in the long tradition of fascicles on tumor pathology published by the Armed Forces of Pathology in Bethesda over the last 50 years. Among the first series was the loose-leaved fascicle by Kernohan and Sayre, published in 1952, setting out the grading system for central nervous system (CNS) tumours that is still used today, although in a modified form. Peter Burger and Bernd Scheithauer have had a long association with the AFIP series as authors of the third series. Many readers will be familiar with the soft cream covers of the third series of the AFIP tumour fascicles that were sold at very low cost. This has changed with the present series which is published in hardback volumes with full-colour illustrations. What has not changed is the stated objective of the series. The aims, set out in the Editors’ Note at the front of the book, are to provide practicing pathologists with thorough concise up-to-date information on the nomenclature and classification, epidemiological, clinical and pathogenetic features of tumours and tumour-like lesions of the CNS and guidance in their diagnosis. There is also an emphasis on the cytopathological features that are so important for intraoperative diagnoses, and a stress upon the genetic features that are valuable for determining diagnosis and prognosis of the variety of tumours affecting the nervous system. Perhaps the first thing to say about this book is that it is beautiful to handle. Good-quality, coffee stain-resistant paper shows off the well-displayed colour images and radiology to great advantage and the book's strong outer cover means that it will withstand extensive use. The book begins with a clear display of the World Health Organzation (WHO) (2007) Classification of Tumours of the Nervous System and an optimistic overview of therapy. This is followed by a well-thought-out chapter on embryology and normal anatomy that includes practical information on radiology, age changes in the brain and useful comments about regional variations and histological artefacts. Subsequent chapters in the first half of the book follow the mainstream WHO classification with some variation particularly in the section on astrocytic tumours in which the authors divide their descriptions, for pragmatic reasons, into diffuse and well-circumscribed tumours. Later chapters are descriptions of tumours and the wide variety of tumour-like lesions seen in diagnostic neuropathology practice. The comprehensive coverage of non-neoplastic lesions that enter the differential diagnosis of CNS malignancies includes vascular malformations, tumour-like lesions of maldevelopmental or uncertain origin and benign cystic lesions. A chapter on reactive and inflammatory masses is excellent. It covers a wide range of relevant entities, including demyelination, infarction, progressive multifocal leukoencephalopathy, lymphoplasmacyte-rich lesions, xanthomatous lesions, collagen vascular disease and radionecrosis. Descriptions of the various entities follow a consistent format. Each entry begins with a definition of the tumour or lesion and is followed by subsections covering clinical features, radiological findings, macroscopic, histological and frozen section appearances. There is extensive coverage of immunohistochemical, ultrastructural and cytological features that are essential for differential diagnoses. Pertinent advice is given on treatment and prognosis of a wide range of lesions and this is particularly useful for pathologists working as part of a multidisciplinary clinical team. Additional subsections address issues relating to grading of lesions and their molecular genetics. Each subsection heading is highlighted in bold text that makes it easy for the reader to quickly identify areas of interest, and each chapter ends with a comprehensive and up-to-date bibliography. At the end of the book, there is a series of 15 excellent appendices that list or describe lesions by their degrees of circumscription, location, macroscopic features and histological appearances. Also, for example, cystic lesions and tumours that are frequently calcified or contain ganglion cells are tabulated in the appendices. Two particularly useful appendices cover low-grade tumours that are potentially misdiagnosed as aggressive or anaplastic neoplasms and non-neoplastic lesions that are potentially misinterpreted as neoplasms. There are a number of interesting differences between the AFIP Atlas and the recently published WHO book on tumours of the CNS. The WHO book is a multi-author volume with a succinct style presenting facts in a well-ordered format serviced by a comprehensive index and bibliography. In contrast, the present AFIP Atlas is much more personal in its style; it is as if the readers were sitting at the microscope and sharing intimate moments in Drs Burger and Scheithauer's long and wide experience of tumours of the nervous system. There is a huge amount of practical advice in this book, but the reader needs to enter into the spirit and ethos of the authors’ approach to derive maximum benefit. Has the book fulfilled the promise of the Editor's Note? Yes, most certainly. Overall, the AFIP Atlas is an excellent textbook, both in terms of style and content. It is practical, comprehensive, well written and very well illustrated. It is written in such a way that it should appeal to both trainees and the experienced consultants. This is the sort of book that will always be within easy reach of your microscope. It offers good value for money and it will be stiff competition for other equivalent textbooks. We recommend it highly." @default.
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• W1624147664 title "Tumors of the Central Nervous System (AFIP Atlas of Tumor Pathology, Series 4. Fascicle 7)" @default.
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