Matches in SemOpenAlex for { <https://semopenalex.org/work/W1624431004> ?p ?o ?g. }
- W1624431004 endingPage "1418" @default.
- W1624431004 startingPage "1413" @default.
- W1624431004 abstract "Abstract Human C-reactive protein (CRP) at acute phase levels of 10–200 μg/ml triggered the phosphorylation of FcγRIIa, Syk kinase, and phospholipase Cγ2 in granulocytic HL-60 cells. CRP also stimulated translocation to the membrane of both phospholipase Cγ2 and phosphatidylinositol-3-kinase. The signaling response triggered by CRP was a rapid, early event with kinetics similar to the response elicited by human IgG. Both soluble-aggregated CRP and monomeric CRP cross-linked FcγRII to generate a signal of the same intensity. The results are consistent with signaling through the intrinsic immunoreceptor tyrosine-based activation motif of the cytoplasmic domain of FcγRIIa, the major CRP-receptor on monocytes and neutrophils that is responsible for CRP-mediated phagocytosis. The signaling events driven by CRP have the potential to regulate infiltrating neutrophil activities." @default.
- W1624431004 created "2016-06-24" @default.
- W1624431004 creator A5015697739 @default.
- W1624431004 creator A5018200317 @default.
- W1624431004 creator A5018353883 @default.
- W1624431004 creator A5027130071 @default.
- W1624431004 creator A5039403146 @default.
- W1624431004 date "2002-02-01" @default.
- W1624431004 modified "2023-10-16" @default.
- W1624431004 title "C-Reactive Protein Induces Signaling Through FcγRIIa on HL-60 Granulocytes" @default.
- W1624431004 cites W1502581005 @default.
- W1624431004 cites W1515006217 @default.
- W1624431004 cites W1522933334 @default.
- W1624431004 cites W1525915247 @default.
- W1624431004 cites W1531208435 @default.
- W1624431004 cites W1564132479 @default.
- W1624431004 cites W1568605582 @default.
- W1624431004 cites W1579377762 @default.
- W1624431004 cites W1584299711 @default.
- W1624431004 cites W1589063951 @default.
- W1624431004 cites W1601220576 @default.
- W1624431004 cites W1605265651 @default.
- W1624431004 cites W1773256867 @default.
- W1624431004 cites W1903287340 @default.
- W1624431004 cites W1928679615 @default.
- W1624431004 cites W1964336741 @default.
- W1624431004 cites W1967641907 @default.
- W1624431004 cites W1981182586 @default.
- W1624431004 cites W1991464867 @default.
- W1624431004 cites W1992605956 @default.
- W1624431004 cites W1993060519 @default.
- W1624431004 cites W2002884360 @default.
- W1624431004 cites W2004921431 @default.
- W1624431004 cites W2044204097 @default.
- W1624431004 cites W2047522139 @default.
- W1624431004 cites W2053706055 @default.
- W1624431004 cites W2053961617 @default.
- W1624431004 cites W2063919406 @default.
- W1624431004 cites W2089783130 @default.
- W1624431004 cites W2098881719 @default.
- W1624431004 cites W2104149109 @default.
- W1624431004 cites W2104603012 @default.
- W1624431004 cites W2106421604 @default.
- W1624431004 cites W2111449472 @default.
- W1624431004 cites W2127618101 @default.
- W1624431004 cites W2141260882 @default.
- W1624431004 cites W2149737394 @default.
- W1624431004 cites W2150411806 @default.
- W1624431004 cites W2154901790 @default.
- W1624431004 cites W2169280145 @default.
- W1624431004 cites W2170992468 @default.
- W1624431004 cites W2171146037 @default.
- W1624431004 cites W2317184793 @default.
- W1624431004 cites W2338533299 @default.
- W1624431004 cites W405865305 @default.
- W1624431004 doi "https://doi.org/10.4049/jimmunol.168.3.1413" @default.
- W1624431004 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11801683" @default.
- W1624431004 hasPublicationYear "2002" @default.
- W1624431004 type Work @default.
- W1624431004 sameAs 1624431004 @default.
- W1624431004 citedByCount "52" @default.
- W1624431004 countsByYear W16244310042012 @default.
- W1624431004 countsByYear W16244310042013 @default.
- W1624431004 countsByYear W16244310042014 @default.
- W1624431004 countsByYear W16244310042017 @default.
- W1624431004 countsByYear W16244310042018 @default.
- W1624431004 countsByYear W16244310042019 @default.
- W1624431004 countsByYear W16244310042021 @default.
- W1624431004 crossrefType "journal-article" @default.
- W1624431004 hasAuthorship W1624431004A5015697739 @default.
- W1624431004 hasAuthorship W1624431004A5018200317 @default.
- W1624431004 hasAuthorship W1624431004A5018353883 @default.
- W1624431004 hasAuthorship W1624431004A5027130071 @default.
- W1624431004 hasAuthorship W1624431004A5039403146 @default.
- W1624431004 hasBestOaLocation W16244310041 @default.
- W1624431004 hasConcept C11960822 @default.
- W1624431004 hasConcept C12927208 @default.
- W1624431004 hasConcept C160448771 @default.
- W1624431004 hasConcept C170493617 @default.
- W1624431004 hasConcept C181199279 @default.
- W1624431004 hasConcept C184235292 @default.
- W1624431004 hasConcept C185592680 @default.
- W1624431004 hasConcept C203014093 @default.
- W1624431004 hasConcept C2777553839 @default.
- W1624431004 hasConcept C2778597717 @default.
- W1624431004 hasConcept C2780610907 @default.
- W1624431004 hasConcept C29907709 @default.
- W1624431004 hasConcept C35174551 @default.
- W1624431004 hasConcept C42362537 @default.
- W1624431004 hasConcept C55493867 @default.
- W1624431004 hasConcept C62478195 @default.
- W1624431004 hasConcept C86803240 @default.
- W1624431004 hasConcept C95444343 @default.
- W1624431004 hasConceptScore W1624431004C11960822 @default.
- W1624431004 hasConceptScore W1624431004C12927208 @default.
- W1624431004 hasConceptScore W1624431004C160448771 @default.
- W1624431004 hasConceptScore W1624431004C170493617 @default.
- W1624431004 hasConceptScore W1624431004C181199279 @default.