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• W1625079248 abstract "This chapter presents the systematic mutational analyses of protein–protein interfaces. Mutational analysis is a powerful approach for identifying protein–protein interfaces. A scanning-mutagenesis method is applied to the interactions between human growth hormone (hGH) and its receptors. Molecular recognition is a key component in virtually all biochemical processes, many of which involve protein–protein interactions. Defining these interactions requires both a high-resolution structure showing the positions of interacting groups and detailed functional data giving the energetic importance of amino acid side chains at or near the interface. Generally, the latter information is more easily obtained if one has a suitable expression system and a simple method for analyzing or screening for binding. The chapter focuses on mutational strategies for obtaining high-resolution functional data about a molecular interface for binding domains under approximately 60 kDa. Such information is immediately useful for probing biochemical mechanisms and designing new protein binding specificities." @default.
• W1625079248 created "2016-06-24" @default.
• W1625079248 creator A5055441920 @default.
• W1625079248 date "1991-01-01" @default.
• W1625079248 modified "2023-10-15" @default.
• W1625079248 title "[18] Systematic mutational analyses of protein-protein interfaces" @default.
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• W1625079248 doi "https://doi.org/10.1016/0076-6879(91)02020-a" @default.
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