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• W1625157788 abstract "Protein fractions washed from the free small ribosome subunits present in a reticulocyte lysate, with 40 S and 60 S ribosome subunits and 9 S RNA from reticulocyte polysomes, promote the initiation of synthesis in vitro of both the α and β chains of rabbit hemoglobin. Changing relative concentrations of 9 S RNA, polysome-derived ribosome subunits, and different initiation factor fractions cause changes in the ratio of α- to β-globin product synthesized. Increasing 9 S RNA concentration with constant ribosome subunit and initiation factor concentration causes a decreasing ratio of α to β product, whereas increasing ribosome subunit concentration with constant 9 S RNA and initiation factor concentration promotes an increasing ratio of α to β product. Increasing levels of derived 40 S subunits relative to derived 60 S subunits with constant 9 S RNA and initiation factor concentration causes an increase in ratio of α to β product. Increasing levels of derived 60 S subunits relative to 40 S subunits causes a small decrease in ratio of α- to β-globin synthesized. In addition, the ratio of α- to β-globin synthesized is affected by the relative amounts of two separate fractions of the salt wash from the free small subunits. Increasing levels of a fraction containing a factor which inhibits the spontaneous association of polysome-derived 40 S subunits with 60 S subunits into single ribosomes causes an increase in the ratio of α- to β-globin product synthesized. The Mg2+ and K+ concentrations have marked effects on the ratio of α- to β-globin synthesized. The results are discussed in terms of (a) different affinities of the initiation sites of α- and β-mRNA for ribosome subunits active in initiation; (b) different availabilities of initiation sites of α- and β-mRNA to the initiating ribosome subunits; and (c) the concentration of ribosome subunits available to interact with the initiation sites of mRNA." @default.
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• W1625157788 date "1974-10-01" @default.
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• W1625157788 title "Regulation of Hemoglobin Synthesis" @default.
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• W1625157788 doi "https://doi.org/10.1016/s0021-9258(19)42187-x" @default.
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