FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1625443668> ?p ?o ?g. }

• W1625443668 endingPage "400" @default.
• W1625443668 startingPage "392" @default.
• W1625443668 abstract "Glioblastomas express a notable heterogeneity in both the histological and cell patterns with glial astrocytic differentiation. Primary glioblastoma, which is the most frequent presentation (90-95%), occurs mainly in older patients and arises de novo, without any clinical or histological evidence of a less malignant precursor lesion. EGFR amplification has been identified as a genetic hallmark of primary glioblastomas and occurs in 40-60% of cases. However, there exist primary glioblastomas without EGFR amplification/overexpression. The purpose of this study was to stabilize the association between cases with and without EGFR gene amplification with clinical and genetic parameters in 45 cases of primary glioblastomas. EGFR amplification was observed in 24 cases (53%), while in the remaining 21 cases (47%) this alteration was not displayed. And whereas EGFR was overexpressed in 79% of cases with EGFR amplification, only 33% of the cases without EGFR amplification showed overexpression. The amplification of EGFR was associated with amplifications in MDM2 and CDK4 and a higher percentage of cases with promoter methylation of INK4a. Only one case of glioblastoma with EGFR amplification presented TP53 mutation simultaneously. Seven remaining cases with TP53 mutations were glioblastomas without EGFR amplification. The INK4a, INK4b and ARF deletions were similar in the two groups. Primary glioblastomas with and without EGFR amplification did not show any significant differences in average survival. The genetic studies suggest the existence of molecular subtypes within primary glioblastoma that may, when fully defined, contribute toward the development of drugs that specifically target tumors with divergent genetic profiles." @default.
• W1625443668 created "2016-06-24" @default.
• W1625443668 creator A5022271433 @default.
• W1625443668 creator A5026678848 @default.
• W1625443668 creator A5028326031 @default.
• W1625443668 creator A5036127803 @default.
• W1625443668 creator A5049463307 @default.
• W1625443668 creator A5056045067 @default.
• W1625443668 creator A5057445351 @default.
• W1625443668 creator A5071009359 @default.
• W1625443668 creator A5083024501 @default.
• W1625443668 date "2009-12-28" @default.
• W1625443668 modified "2023-10-15" @default.
• W1625443668 title "Primary glioblastomas with and without EGFR amplification: Relationship to genetic alterations and clinicopathological features" @default.
• W1625443668 cites W197014098 @default.
• W1625443668 cites W1986902967 @default.
• W1625443668 cites W1987047760 @default.
• W1625443668 cites W1994465394 @default.
• W1625443668 cites W2007965086 @default.
• W1625443668 cites W2025183726 @default.
• W1625443668 cites W2034194437 @default.
• W1625443668 cites W2045512452 @default.
• W1625443668 cites W2073771697 @default.
• W1625443668 cites W2082475821 @default.
• W1625443668 cites W2084891010 @default.
• W1625443668 cites W2092918255 @default.
• W1625443668 cites W2105113857 @default.
• W1625443668 cites W2113942802 @default.
• W1625443668 cites W2123151929 @default.
• W1625443668 cites W2136422121 @default.
• W1625443668 cites W2150638747 @default.
• W1625443668 cites W2159355549 @default.
• W1625443668 doi "https://doi.org/10.1111/j.1440-1789.2009.01081.x" @default.
• W1625443668 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20051017" @default.
• W1625443668 hasPublicationYear "2009" @default.
• W1625443668 type Work @default.
• W1625443668 sameAs 1625443668 @default.
• W1625443668 citedByCount "37" @default.
• W1625443668 countsByYear W16254436682012 @default.
• W1625443668 countsByYear W16254436682013 @default.
• W1625443668 countsByYear W16254436682014 @default.
• W1625443668 countsByYear W16254436682015 @default.
• W1625443668 countsByYear W16254436682016 @default.
• W1625443668 countsByYear W16254436682017 @default.
• W1625443668 countsByYear W16254436682018 @default.
• W1625443668 countsByYear W16254436682019 @default.
• W1625443668 countsByYear W16254436682020 @default.
• W1625443668 countsByYear W16254436682021 @default.
• W1625443668 crossrefType "journal-article" @default.
• W1625443668 hasAuthorship W1625443668A5022271433 @default.
• W1625443668 hasAuthorship W1625443668A5026678848 @default.
• W1625443668 hasAuthorship W1625443668A5028326031 @default.
• W1625443668 hasAuthorship W1625443668A5036127803 @default.
• W1625443668 hasAuthorship W1625443668A5049463307 @default.
• W1625443668 hasAuthorship W1625443668A5056045067 @default.
• W1625443668 hasAuthorship W1625443668A5057445351 @default.
• W1625443668 hasAuthorship W1625443668A5071009359 @default.
• W1625443668 hasAuthorship W1625443668A5083024501 @default.
• W1625443668 hasConcept C104317684 @default.
• W1625443668 hasConcept C121608353 @default.
• W1625443668 hasConcept C142724271 @default.
• W1625443668 hasConcept C2776192174 @default.
• W1625443668 hasConcept C2776194525 @default.
• W1625443668 hasConcept C2779438470 @default.
• W1625443668 hasConcept C501734568 @default.
• W1625443668 hasConcept C502942594 @default.
• W1625443668 hasConcept C54355233 @default.
• W1625443668 hasConcept C71924100 @default.
• W1625443668 hasConcept C7602840 @default.
• W1625443668 hasConcept C86803240 @default.
• W1625443668 hasConceptScore W1625443668C104317684 @default.
• W1625443668 hasConceptScore W1625443668C121608353 @default.
• W1625443668 hasConceptScore W1625443668C142724271 @default.
• W1625443668 hasConceptScore W1625443668C2776192174 @default.
• W1625443668 hasConceptScore W1625443668C2776194525 @default.
• W1625443668 hasConceptScore W1625443668C2779438470 @default.
• W1625443668 hasConceptScore W1625443668C501734568 @default.
• W1625443668 hasConceptScore W1625443668C502942594 @default.
• W1625443668 hasConceptScore W1625443668C54355233 @default.
• W1625443668 hasConceptScore W1625443668C71924100 @default.
• W1625443668 hasConceptScore W1625443668C7602840 @default.
• W1625443668 hasConceptScore W1625443668C86803240 @default.
• W1625443668 hasIssue "4" @default.
• W1625443668 hasLocation W16254436681 @default.
• W1625443668 hasLocation W16254436682 @default.
• W1625443668 hasOpenAccess W1625443668 @default.
• W1625443668 hasPrimaryLocation W16254436681 @default.
• W1625443668 hasRelatedWork W1912284124 @default.
• W1625443668 hasRelatedWork W2004771658 @default.
• W1625443668 hasRelatedWork W2049372674 @default.
• W1625443668 hasRelatedWork W2064876412 @default.
• W1625443668 hasRelatedWork W2163125688 @default.
• W1625443668 hasRelatedWork W2171277769 @default.
• W1625443668 hasRelatedWork W2304205445 @default.
• W1625443668 hasRelatedWork W3113389551 @default.
• W1625443668 hasRelatedWork W2443343736 @default.
• W1625443668 hasRelatedWork W4214789906 @default.
• W1625443668 hasVolume "30" @default.

• next