FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1625736061> ?p ?o ?g. }

• W1625736061 endingPage "2162" @default.
• W1625736061 startingPage "2157" @default.
• W1625736061 abstract "As human fibroblasts in culture senesce their response to platelet-derived growth factor (PDGF) becomes attenuated. To clarify at which level such cells are blocked in the pre-replicative part of the cell cycle, we have analysed PDGF-induced pre-replicative events in senescent (phase III) cultures. We found that phase III cells retain a normal number of PDGF receptors and that these are functional with regard to PDGF-induced receptor autophosphorylation. Phase III cells also respond to PDGF by rapid actin reorganization and increased levels of c-fos and c-myc mRNA, similar to growth-arrested phase II fibroblasts. However, the expression of the nuclear antigen K-67, which in phase II cell is induced in S-phase and continues to be expressed throughout the cell cycle, is not induced in phase III cells in response to PDGF. We conclude that phase III human fibroblasts, although blocked with regard to proliferation, still retain a functional growth factor receptor system, and display early responses when exposed to growth factors, such as changes in the cytoskeleton and the expression of proto-oncogenes." @default.
• W1625736061 created "2016-06-24" @default.
• W1625736061 creator A5006798806 @default.
• W1625736061 creator A5017766936 @default.
• W1625736061 creator A5026265347 @default.
• W1625736061 creator A5047814563 @default.
• W1625736061 creator A5051005847 @default.
• W1625736061 creator A5054367458 @default.
• W1625736061 creator A5071980236 @default.
• W1625736061 creator A5090354704 @default.
• W1625736061 date "1986-09-01" @default.
• W1625736061 modified "2023-10-15" @default.
• W1625736061 title "Growth factors induce early pre-replicative changes in senescent human fibroblasts." @default.
• W1625736061 cites W1528220837 @default.
• W1625736061 cites W1537531528 @default.
• W1625736061 cites W1967925725 @default.
• W1625736061 cites W1969702279 @default.
• W1625736061 cites W1976245365 @default.
• W1625736061 cites W1978440762 @default.
• W1625736061 cites W1986654313 @default.
• W1625736061 cites W1990205754 @default.
• W1625736061 cites W1992280915 @default.
• W1625736061 cites W2003124778 @default.
• W1625736061 cites W2004182244 @default.
• W1625736061 cites W2013248690 @default.
• W1625736061 cites W2013932828 @default.
• W1625736061 cites W2018437033 @default.
• W1625736061 cites W2021253208 @default.
• W1625736061 cites W2057952696 @default.
• W1625736061 cites W2070341388 @default.
• W1625736061 cites W2072262157 @default.
• W1625736061 cites W2072808743 @default.
• W1625736061 cites W2073021571 @default.
• W1625736061 cites W2082826626 @default.
• W1625736061 cites W2092461082 @default.
• W1625736061 cites W2126486896 @default.
• W1625736061 cites W2130581660 @default.
• W1625736061 cites W2146923243 @default.
• W1625736061 cites W2154536753 @default.
• W1625736061 cites W2164515753 @default.
• W1625736061 doi "https://doi.org/10.1002/j.1460-2075.1986.tb04479.x" @default.
• W1625736061 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1167095" @default.
• W1625736061 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3023058" @default.
• W1625736061 hasPublicationYear "1986" @default.
• W1625736061 type Work @default.
• W1625736061 sameAs 1625736061 @default.
• W1625736061 citedByCount "57" @default.
• W1625736061 countsByYear W16257360612013 @default.
• W1625736061 countsByYear W16257360612014 @default.
• W1625736061 countsByYear W16257360612015 @default.
• W1625736061 crossrefType "journal-article" @default.
• W1625736061 hasAuthorship W1625736061A5006798806 @default.
• W1625736061 hasAuthorship W1625736061A5017766936 @default.
• W1625736061 hasAuthorship W1625736061A5026265347 @default.
• W1625736061 hasAuthorship W1625736061A5047814563 @default.
• W1625736061 hasAuthorship W1625736061A5051005847 @default.
• W1625736061 hasAuthorship W1625736061A5054367458 @default.
• W1625736061 hasAuthorship W1625736061A5071980236 @default.
• W1625736061 hasAuthorship W1625736061A5090354704 @default.
• W1625736061 hasBestOaLocation W16257360611 @default.
• W1625736061 hasConcept C11960822 @default.
• W1625736061 hasConcept C1491633281 @default.
• W1625736061 hasConcept C150109051 @default.
• W1625736061 hasConcept C153911025 @default.
• W1625736061 hasConcept C170493617 @default.
• W1625736061 hasConcept C180361614 @default.
• W1625736061 hasConcept C2775960820 @default.
• W1625736061 hasConcept C2781294074 @default.
• W1625736061 hasConcept C29537977 @default.
• W1625736061 hasConcept C54355233 @default.
• W1625736061 hasConcept C62112901 @default.
• W1625736061 hasConcept C81885089 @default.
• W1625736061 hasConcept C86803240 @default.
• W1625736061 hasConcept C95444343 @default.
• W1625736061 hasConcept C97029542 @default.
• W1625736061 hasConceptScore W1625736061C11960822 @default.
• W1625736061 hasConceptScore W1625736061C1491633281 @default.
• W1625736061 hasConceptScore W1625736061C150109051 @default.
• W1625736061 hasConceptScore W1625736061C153911025 @default.
• W1625736061 hasConceptScore W1625736061C170493617 @default.
• W1625736061 hasConceptScore W1625736061C180361614 @default.
• W1625736061 hasConceptScore W1625736061C2775960820 @default.
• W1625736061 hasConceptScore W1625736061C2781294074 @default.
• W1625736061 hasConceptScore W1625736061C29537977 @default.
• W1625736061 hasConceptScore W1625736061C54355233 @default.
• W1625736061 hasConceptScore W1625736061C62112901 @default.
• W1625736061 hasConceptScore W1625736061C81885089 @default.
• W1625736061 hasConceptScore W1625736061C86803240 @default.
• W1625736061 hasConceptScore W1625736061C95444343 @default.
• W1625736061 hasConceptScore W1625736061C97029542 @default.
• W1625736061 hasIssue "9" @default.
• W1625736061 hasLocation W16257360611 @default.
• W1625736061 hasLocation W16257360612 @default.
• W1625736061 hasLocation W16257360613 @default.
• W1625736061 hasOpenAccess W1625736061 @default.
• W1625736061 hasPrimaryLocation W16257360611 @default.
• W1625736061 hasRelatedWork W1604172326 @default.
• W1625736061 hasRelatedWork W1988539054 @default.

• next