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- W1626100834 abstract "Introduction remains a serious, ultimately lethal pandemic disease in much of the developing world. Significant treatment advances have been made with antiretroviral agents, but major problems remain. These treatments are expensive and difficult to apply especially for developing world nations that lack adequate finances and infrastructure, do not eliminate all virus and therefore require life long treatment regimens, carry significant toxic side effects and in some quarters becoming less effective due to viral mutation. There remains a major need to identify effective measures to prevent new HIV infections, especially in areas of the world where it is a pandemic. Based on the history of vaccine development, it remains a strong consensus in the biomedical research community that immunization will provide the most effective and affordable long term-approach to controlling the spread of HIV/AIDS. Strong cytotoxic T-lymphocyte (CTL) responses are thought to be important for the development of an effective human immunodeficiency virus (HIV) vaccine; their benefit has been established in simian immunodeficiency virus (SIV) vaccination studies and in natural infections [1,2]. One of our major goals is to identify optimized, highly immunogenic peptides for the design of prophylactic or therapeutic vaccines for HIV infection. Our strategy derives from the hypothesis that the rarer mutant CTL epitopes of HIV may be more immunogenic than the common ones and that these rarer mutant sequences of HIV epitopes might be more effective in generating cross reactive anti-HIV CTL responses against both the rare and common mutant sequences." @default.
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- W1626100834 date "2009-01-01" @default.
- W1626100834 modified "2023-10-18" @default.
- W1626100834 title "Natural mutants of HIV CTL epitopes with enhanced immunogenicity as potential vaccine candidates" @default.
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- W1626100834 doi "https://doi.org/10.1007/978-0-387-73657-0_166" @default.
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