FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1626137351> ?p ?o ?g. }

• W1626137351 endingPage "3095" @default.
• W1626137351 startingPage "3090" @default.
• W1626137351 abstract "Multiplication-stimulating activity (MSA) stimulates the uptake of xylose and alpha-aminoisobutyric acid (AIB) by intact rat soleus muscle. It is approximately 50 times less potent than insulin. A native insulin receptor species with apparent Mr = 350,000 in soleus muscle is revealed by affinity cross-linking to 125I-insulin with disuccinimidyl suberate. 125I-labeled insulin-like growth factor (IGF) I with the cross-linker affinity labels two native receptor types with Mr = 360,000 (type I) and Mr = 220,000 (type II). In order to distinguish which of the three insulin and IGF receptor systems identified mediate the rapid insulin-like effects of MSA, the biological actions of the unlabeled ligands at various concentrations were correlated with their ability to inhibit the affinity labeling of these receptor species. The stimulatory action of native insulin is closely related to its ability to inhibit the labeling of the insulin receptor by 125I-insulin such that the uptake of xylose and AIB is maximally stimulated when 80% of insulin receptor 125I-affinity labeling is inhibited. In contrast, MSA only displaced 16% of the 125I-labeling of the insulin receptor when it maximally stimulates the uptake of xylose and AIB, indicating that the insulin receptor is not primarily involved in mediating these effects. The affinity of MSA to the type II IGF receptor is 10 times higher than that to the type I IGF receptor. There is close to a 1:1 relationship between the stimulatory effects of MSA on xylose and AIB uptake and its inhibitory action on the affinity labeling of the type I receptor by 125I-IGF I. In contrast, MSA almost abolishes the labeling of the type II IGF receptor at concentrations which have no detectable effects on the uptake of xylose and AIB by soleus muscle. Thus, a marked dissociation can be observed between the rapid insulin-like action of MSA and its inhibitory effects on the affinity labeling of the type II receptor by 125I-IGF I. We conclude that MSA acts through the type I IGF receptor in soleus muscle to stimulate hexose and amino acid transport. The type II IGF receptor appears to be incapable of modulating these effects in this tissue." @default.
• W1626137351 created "2016-06-24" @default.
• W1626137351 creator A5010431691 @default.
• W1626137351 creator A5085687728 @default.
• W1626137351 date "1984-03-01" @default.
• W1626137351 modified "2023-10-15" @default.
• W1626137351 title "The type I insulin-like growth factor receptor mediates the rapid effects of multiplication-stimulating activity on membrane transport systems in rat soleus muscle." @default.
• W1626137351 cites W1480810179 @default.
• W1626137351 cites W1488424161 @default.
• W1626137351 cites W1494815324 @default.
• W1626137351 cites W1500990165 @default.
• W1626137351 cites W1508807714 @default.
• W1626137351 cites W1523972021 @default.
• W1626137351 cites W1526566805 @default.
• W1626137351 cites W1566856537 @default.
• W1626137351 cites W1672662520 @default.
• W1626137351 cites W1965259964 @default.
• W1626137351 cites W1972454974 @default.
• W1626137351 cites W1977000145 @default.
• W1626137351 cites W1981171882 @default.
• W1626137351 cites W2005370615 @default.
• W1626137351 cites W2015316688 @default.
• W1626137351 cites W2019087981 @default.
• W1626137351 cites W2029772086 @default.
• W1626137351 cites W2039726303 @default.
• W1626137351 cites W2049191075 @default.
• W1626137351 cites W2053134566 @default.
• W1626137351 cites W2054350936 @default.
• W1626137351 cites W2073691118 @default.
• W1626137351 cites W2089751119 @default.
• W1626137351 cites W2090532551 @default.
• W1626137351 cites W2100837269 @default.
• W1626137351 cites W2100921799 @default.
• W1626137351 cites W2124828486 @default.
• W1626137351 cites W2125632609 @default.
• W1626137351 doi "https://doi.org/10.1016/s0021-9258(17)43264-9" @default.
• W1626137351 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6321495" @default.
• W1626137351 hasPublicationYear "1984" @default.
• W1626137351 type Work @default.
• W1626137351 sameAs 1626137351 @default.
• W1626137351 citedByCount "93" @default.
• W1626137351 countsByYear W16261373512013 @default.
• W1626137351 crossrefType "journal-article" @default.
• W1626137351 hasAuthorship W1626137351A5010431691 @default.
• W1626137351 hasAuthorship W1626137351A5085687728 @default.
• W1626137351 hasBestOaLocation W16261373511 @default.
• W1626137351 hasConcept C121332964 @default.
• W1626137351 hasConcept C12554922 @default.
• W1626137351 hasConcept C126322002 @default.
• W1626137351 hasConcept C134018914 @default.
• W1626137351 hasConcept C161573976 @default.
• W1626137351 hasConcept C170493617 @default.
• W1626137351 hasConcept C185592680 @default.
• W1626137351 hasConcept C24890656 @default.
• W1626137351 hasConcept C2775960820 @default.
• W1626137351 hasConcept C2776104385 @default.
• W1626137351 hasConcept C2779306644 @default.
• W1626137351 hasConcept C2779959927 @default.
• W1626137351 hasConcept C2780595030 @default.
• W1626137351 hasConcept C2780689927 @default.
• W1626137351 hasConcept C55493867 @default.
• W1626137351 hasConcept C71924100 @default.
• W1626137351 hasConcept C86803240 @default.
• W1626137351 hasConcept C95444343 @default.
• W1626137351 hasConceptScore W1626137351C121332964 @default.
• W1626137351 hasConceptScore W1626137351C12554922 @default.
• W1626137351 hasConceptScore W1626137351C126322002 @default.
• W1626137351 hasConceptScore W1626137351C134018914 @default.
• W1626137351 hasConceptScore W1626137351C161573976 @default.
• W1626137351 hasConceptScore W1626137351C170493617 @default.
• W1626137351 hasConceptScore W1626137351C185592680 @default.
• W1626137351 hasConceptScore W1626137351C24890656 @default.
• W1626137351 hasConceptScore W1626137351C2775960820 @default.
• W1626137351 hasConceptScore W1626137351C2776104385 @default.
• W1626137351 hasConceptScore W1626137351C2779306644 @default.
• W1626137351 hasConceptScore W1626137351C2779959927 @default.
• W1626137351 hasConceptScore W1626137351C2780595030 @default.
• W1626137351 hasConceptScore W1626137351C2780689927 @default.
• W1626137351 hasConceptScore W1626137351C55493867 @default.
• W1626137351 hasConceptScore W1626137351C71924100 @default.
• W1626137351 hasConceptScore W1626137351C86803240 @default.
• W1626137351 hasConceptScore W1626137351C95444343 @default.
• W1626137351 hasIssue "5" @default.
• W1626137351 hasLocation W16261373511 @default.
• W1626137351 hasOpenAccess W1626137351 @default.
• W1626137351 hasPrimaryLocation W16261373511 @default.
• W1626137351 hasRelatedWork W2014231481 @default.
• W1626137351 hasRelatedWork W2058160713 @default.
• W1626137351 hasRelatedWork W2099817208 @default.
• W1626137351 hasRelatedWork W2119436088 @default.
• W1626137351 hasRelatedWork W2121592873 @default.
• W1626137351 hasRelatedWork W2130733926 @default.
• W1626137351 hasRelatedWork W2590769241 @default.
• W1626137351 hasRelatedWork W2800670286 @default.
• W1626137351 hasRelatedWork W2982823661 @default.
• W1626137351 hasRelatedWork W2189320406 @default.
• W1626137351 hasVolume "259" @default.
• W1626137351 isParatext "false" @default.

• next