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- W162632653 abstract "This chapter presents the tests and functions of thyroid. Nearly all the circulating, organically bound iodine is normally incorporated in thyroxine (T4). More than 99% of this T4 is bound to a specific thyroxine-binding globulin (TBG); this bound T4 is physiologically inactive. The protein-bound fraction is in equilibrium with very small amount of free, physiologically active hormone. Triiodothyronine (T3) accounts for the remaining small amount (about 1–5%) of circulating organic iodine, and is bound to TBG in about the same proportion as T4; on a molar basis free T3 is physiologically more active than free T4. The binding protein is about a third saturated with hormone. Circulating inorganic iodide is utilized by the thyroid gland to synthesize T4 and T3. It is taken up by, and concentrated in, the thyroid cells by an active transport process. Iodide is converted to iodine and is incorporated into tyrosine to form mono- and di-iodotyrosine. Condensation of two iodinated tyrosine molecules forms T4 (two di-iodotyrosine) and T3 (one mono- and one di-iodotyrosine), which are stored in the gland, bound to protein as thyroglobulin. This overall process may be affected in a variety of ways." @default.
- W162632653 created "2016-06-24" @default.
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- W162632653 date "1979-01-01" @default.
- W162632653 modified "2023-09-24" @default.
- W162632653 title "THYROID, TESTS OF FUNCTION OF" @default.
- W162632653 doi "https://doi.org/10.1016/b978-0-7236-0490-7.50317-7" @default.
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