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- W1626352259 abstract "Publisher Summary Severe spinal cord injury, such as a complete transection, can disrupt descending command axons, and this leads to paralysis below the lesion. The degree of behavioral recovery following spinal cord injury depends on the phylogeny and developmental stage of the animal. Lampreys begin to recover locomotor function about 2 weeks following complete transections of the rostra1 spinal cord at 10% body length (BL). Initially, locomotor movements are attenuated, particularly in the caudal half of the body, and muscle activity is limited to a few millimeters below the transection. Between 2 and 8 weeks post-transection (PT), locomotor movements and locomotor activity are gradually restored to normal along the body. Locomotor activity from in vitro brain/spinal cord preparations occurs at progressively greater distances below the transaction with increasing recovery times, but with a slower time course than in whole animals. Anatomical experiments using retrograde tracers and double labeling experiments indicate that several mechanisms contribute to recovery of locomotor function in spinal cordtransected lamprey: regeneration of descending axons from brainstem command neurons; descending propriospinal relay neurons; and mechanosensory inputs." @default.
- W1626352259 created "2016-06-24" @default.
- W1626352259 creator A5006351455 @default.
- W1626352259 date "1994-01-01" @default.
- W1626352259 modified "2023-09-23" @default.
- W1626352259 title "Chapter 17 Functional regeneration and restoration of locomotor activity following spinal cord transection in the lamprey" @default.
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- W1626352259 doi "https://doi.org/10.1016/s0079-6123(08)61137-1" @default.
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