FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1626486549> ?p ?o ?g. }

• W1626486549 endingPage "3138" @default.
• W1626486549 startingPage "3131" @default.
• W1626486549 abstract "Transcription factor NF-kappaB is regulated by a family of inhibitors, IkappaBs, as well as the NF-kappaB1 and NF-kappaB2 precursor proteins, p105 and p100. Although the different NF-kappaB inhibitors can all inhibit NF-kappaB in vitro, their physiological functions are incompletely understood. In this study, we demonstrate that p105 plays an important role in the regulation of T cell homeostasis and prevention of chronic inflammation. Mice lacking p105, but expressing the mature NF-kappaB1 p50, spontaneously develop intestinal inflammation with features of human inflammatory bowel disease. This inflammatory disorder occurs under specific pathogen-free conditions and critically involves T cells. Consistently, the p105-deficient mice have reduced frequency of naive T cells and increased frequency of memory/effector T cells in the peripheral lymphoid organs. Although p105 is dispensable for the production of immunosuppressive regulatory T cells, p105 deficiency renders CD4 T cells more resistant to Treg-mediated inhibition. We further show that the loss of p105 results in hyperproduction of Th17 subset of inflammatory T cells. Together, these findings suggest a critical role for NF-kappaB1 p105 in the regulation of T cell homeostasis and differentiation and the control of chronic inflammation." @default.
• W1626486549 created "2016-06-24" @default.
• W1626486549 creator A5026339766 @default.
• W1626486549 creator A5032517991 @default.
• W1626486549 creator A5033074082 @default.
• W1626486549 creator A5082989514 @default.
• W1626486549 creator A5084391269 @default.
• W1626486549 date "2009-03-01" @default.
• W1626486549 modified "2023-10-13" @default.
• W1626486549 title "NF-κB1 p105 Regulates T Cell Homeostasis and Prevents Chronic Inflammation" @default.
• W1626486549 cites W184020152 @default.
• W1626486549 cites W1959664751 @default.
• W1626486549 cites W1987531976 @default.
• W1626486549 cites W2001192666 @default.
• W1626486549 cites W2005780938 @default.
• W1626486549 cites W2006249161 @default.
• W1626486549 cites W2010896319 @default.
• W1626486549 cites W2019497869 @default.
• W1626486549 cites W2031717064 @default.
• W1626486549 cites W2035033919 @default.
• W1626486549 cites W2035616122 @default.
• W1626486549 cites W2037061225 @default.
• W1626486549 cites W2042166751 @default.
• W1626486549 cites W2046357626 @default.
• W1626486549 cites W2049644460 @default.
• W1626486549 cites W2051831012 @default.
• W1626486549 cites W2054489468 @default.
• W1626486549 cites W2060527543 @default.
• W1626486549 cites W2061702898 @default.
• W1626486549 cites W2062517636 @default.
• W1626486549 cites W2065307318 @default.
• W1626486549 cites W2068521142 @default.
• W1626486549 cites W2070715537 @default.
• W1626486549 cites W2073427170 @default.
• W1626486549 cites W2074067501 @default.
• W1626486549 cites W2074150439 @default.
• W1626486549 cites W2076517048 @default.
• W1626486549 cites W2076519131 @default.
• W1626486549 cites W2077453377 @default.
• W1626486549 cites W2081521873 @default.
• W1626486549 cites W2091694934 @default.
• W1626486549 cites W2095880232 @default.
• W1626486549 cites W2106471879 @default.
• W1626486549 cites W2117327528 @default.
• W1626486549 cites W2123166427 @default.
• W1626486549 cites W2131678280 @default.
• W1626486549 cites W2136357996 @default.
• W1626486549 cites W2139997445 @default.
• W1626486549 cites W2142017607 @default.
• W1626486549 cites W2148119611 @default.
• W1626486549 cites W2148226248 @default.
• W1626486549 cites W2151088711 @default.
• W1626486549 cites W2153060237 @default.
• W1626486549 cites W4297022993 @default.
• W1626486549 cites W4313335775 @default.
• W1626486549 doi "https://doi.org/10.4049/jimmunol.0803637" @default.
• W1626486549 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2739978" @default.
• W1626486549 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19234210" @default.
• W1626486549 hasPublicationYear "2009" @default.
• W1626486549 type Work @default.
• W1626486549 sameAs 1626486549 @default.
• W1626486549 citedByCount "39" @default.
• W1626486549 countsByYear W16264865492012 @default.
• W1626486549 countsByYear W16264865492013 @default.
• W1626486549 countsByYear W16264865492016 @default.
• W1626486549 countsByYear W16264865492017 @default.
• W1626486549 countsByYear W16264865492018 @default.
• W1626486549 countsByYear W16264865492020 @default.
• W1626486549 countsByYear W16264865492021 @default.
• W1626486549 countsByYear W16264865492022 @default.
• W1626486549 crossrefType "journal-article" @default.
• W1626486549 hasAuthorship W1626486549A5026339766 @default.
• W1626486549 hasAuthorship W1626486549A5032517991 @default.
• W1626486549 hasAuthorship W1626486549A5033074082 @default.
• W1626486549 hasAuthorship W1626486549A5082989514 @default.
• W1626486549 hasAuthorship W1626486549A5084391269 @default.
• W1626486549 hasBestOaLocation W16264865491 @default.
• W1626486549 hasConcept C104317684 @default.
• W1626486549 hasConcept C203014093 @default.
• W1626486549 hasConcept C2776090121 @default.
• W1626486549 hasConcept C2776914184 @default.
• W1626486549 hasConcept C47348012 @default.
• W1626486549 hasConcept C51785407 @default.
• W1626486549 hasConcept C54355233 @default.
• W1626486549 hasConcept C63645605 @default.
• W1626486549 hasConcept C86339819 @default.
• W1626486549 hasConcept C86803240 @default.
• W1626486549 hasConcept C8891405 @default.
• W1626486549 hasConcept C95444343 @default.
• W1626486549 hasConceptScore W1626486549C104317684 @default.
• W1626486549 hasConceptScore W1626486549C203014093 @default.
• W1626486549 hasConceptScore W1626486549C2776090121 @default.
• W1626486549 hasConceptScore W1626486549C2776914184 @default.
• W1626486549 hasConceptScore W1626486549C47348012 @default.
• W1626486549 hasConceptScore W1626486549C51785407 @default.
• W1626486549 hasConceptScore W1626486549C54355233 @default.
• W1626486549 hasConceptScore W1626486549C63645605 @default.
• W1626486549 hasConceptScore W1626486549C86339819 @default.

• next