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- W162659094 abstract "In recent years considerable interest has been shown in the suggestion that the antigens of the HLA system may play a role as a genetic marker in primary affective disorders (PADs). Weak associations between bipolar illness, unipolar depression, or affective illness in general on the one hand and antigens of the HLA-A, -B, or -C loci on the other hand have been found. An increased frequency of HLA-B16 was reported by Shapiro el al. (1976) in Danish PAD patients; Beckman et al. (1978) observed an increased frequency of HLA-A1 and HLA-B7 in Swedish unipolar patients. Majsky et al. (1978) reported increments of HLA-B40 and HLA-Cw4 in Czechoslovakian patients with PADs of bipolar and unipolar form, respectively. In a manicdepressive sample originating from northern Italy, Smeraldi et al. (1978b) found a significantly increased frequency of HLA-A29 and HLA-Bw22 and a decrement of HLA-A9 and HLA-A10. The aim of this study was to investigate the frequencies of various A-and-B-loci antigens, both in affective illness in general and in the bipolar and unipolar forms of the disorder, in a sample of PAD patients originating from central Italy, whose genetic characters are markedly different from those of the northern Italian population." @default.
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- W162659094 date "1985-12-01" @default.
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- W162659094 title "The HLA system as a genetic marker of affective disorders" @default.
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- W162659094 doi "https://doi.org/10.1016/0006-3223(85)90119-2" @default.
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