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- W1626730714 abstract "Abstract Human ficolin-2 is a lectin-complement pathway activator that is present in normal human plasma and is associated with infectious diseases; however, little is known regarding the roles and mechanisms of ficolin-2 during chronic Hepatitis C Virus (HCV) infection. In this study, we found that ficolin-2 could inhibit the entry of HCV at the early stage of virus infection, regardless of the viral genotype. Ficolin-2 neutralized and inhibited the initial attachment and infection of HCV by binding to the HCV envelope surface glycoproteins E1 and E2, blocking HCV attachment to low-density lipoprotein receptor (LDLR) and scavenger receptor (SR-B1), and weakly interfering with CD81 receptor attachment. However, no interference with claudin-1 and occludin receptors attachment was observed. The C-terminal fibrinogen domain of ficolin-2 was identified as the critical binding region for the HCV E1-E2 N-glycans, playing a critical role in the anti-HCV activity. Our data suggest that the HCV entry inhibitor ficolin-2 is a novel and promising antiviral innate immune molecule and the immune escape mechanism mediated by ApoE3 during chronic HCV infection. HCV may be neutralized using compounds directed against the lipoprotein moiety of the viral particle and that ApoE3 may be a new target to combat HCV infection." @default.
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- W1626730714 date "2014-05-01" @default.
- W1626730714 modified "2023-09-25" @default.
- W1626730714 title "ApoE3 blocks HCV entry inhibitor ficolin-2 (INM8P.437)" @default.
- W1626730714 doi "https://doi.org/10.4049/jimmunol.192.supp.124.3" @default.
- W1626730714 hasPublicationYear "2014" @default.
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