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• W1626797621 endingPage "2715" @default.
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• W1626797621 abstract "Effects of daily injections of pituitary-derived bovine somatotropin (bST) for 6 wk were evaluated in 10 growing heifers and compared to 9 placebo-treated control animals. Bovine somatotropin was injected at 50µg/kg BW each day. Body weight and growth, plasma concentrations of insulin-like growth factor I (IGF-I) and somatotropin (ST) were assessed. To measure plasma concentrations of IGF-I, we validated a RIA in which bovine plasma samples were extracted with acid-ethanol, a method that resulted in greater than 90% recovery of IGF-I. Average daily gain was similar during the first 4 wk of the experiment in both control and bST-treated groups; however, at the end of the experimental period (wk 4 and 6) ADG was greater (P < .05) in bST-treated heifers (1.24 ± .21 kg/d vs .75 ± .25 kg/d). Plasma IGF-I from wk 2 to wk 6 were increased in bST-treated animals (452 ± 97 ng/ml at wk 2; 683 ± 106 ng/ml at wk 6) compared with controls (293 ± 62 ng/ml at wk 2 (P < .01) and 293 ± 115 ng/ml at wk 6 (P < .001). Moreover, ADG over the 6-wk experimental period was correlated with mean IGF-I concentrations determined over the same period (r = .55; P < .01). As expected, mean plasma ST concentrations were increased in bST-injected animals from wk 1 to 6. Gel chromatographic profiles of bovine plasma exhibit a 150,000 molecular weight ST-dependent binding protein-IGF-I complex and a 30,000 molecular weight non-ST-dependent complex. This study validates a method for measuring IGF-I in cattle, and shows a positive relationship among IGF-I and ADG after ST treatment. No correlation, however, was found between plasma ST and growth performance." @default.
• W1626797621 created "2016-06-24" @default.
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• W1626797621 date "1989-01-01" @default.
• W1626797621 modified "2023-10-15" @default.
• W1626797621 title "Effect of Pituitary Somatotropin Injections on Plasma Insulin-Like Growth Factor I and Somatotropin Profiles in Growing Heifers" @default.
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• W1626797621 doi "https://doi.org/10.2527/jas1989.67102715x" @default.
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