FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1626851274> ?p ?o ?g. }

• W1626851274 endingPage "496" @default.
• W1626851274 startingPage "487" @default.
• W1626851274 abstract "Identification of prognostic melanoma-associated copy number alterations (CNAs) is still an area of active research. Here, we investigated by high-resolution array comparative genomic hybridization (aCGH) a cohort of 31 paraffin-preserved primary malignant melanomas (MMs), whose prognosis was not predictable on the basis of conventional histopathological parameters. Although we identified a variety of highly recurrent sites of genomic lesions, the total number of CNAs per patient was not a discriminator of MM outcome. Furthermore, validation of aCGH by quantitative PCR on an extended population of 65 MM samples confirmed the absence of predictive value for the most recurrent CNA loci. Instead, our analysis revealed specific prognostic potential of the frequency of homozygous deletions (representing less than 3% of the total CNAs on average per sample), which was strongly associated with sentinel lymph node (SLN) invasion (P = 0.003), and distant metastasis (P = 0.003). Increased number of homozygous deletions was also indicative of poor patient survival (P = 0.01), both in our samples and in an independent validation of public dataset of primary and metastatic MMs. Moreover, we identified 77 hotspots of minimal common homozygous deletions, enriched in genes involved in cell adhesion processes and cell-communication functions, which preferentially accumulated in primary MMs showing the most severe outcome. Therefore, specific loss of gene loci in regions of minimal homozygous deletion may represent a pivotal type of genomic alteration accumulating during MM progression with potential prognostic implication. © 2014 Wiley Periodicals, Inc." @default.
• W1626851274 created "2016-06-24" @default.
• W1626851274 creator A5002300255 @default.
• W1626851274 creator A5005052429 @default.
• W1626851274 creator A5007544895 @default.
• W1626851274 creator A5025742350 @default.
• W1626851274 creator A5027130762 @default.
• W1626851274 creator A5038081503 @default.
• W1626851274 creator A5039627791 @default.
• W1626851274 creator A5081257602 @default.
• W1626851274 creator A5085732836 @default.
• W1626851274 date "2014-02-24" @default.
• W1626851274 modified "2023-10-17" @default.
• W1626851274 title "Increased frequency of minimal homozygous deletions is associated with poor prognosis in primary malignant melanoma patients" @default.
• W1626851274 cites W112527708 @default.
• W1626851274 cites W1490297017 @default.
• W1626851274 cites W1822784852 @default.
• W1626851274 cites W1919139351 @default.
• W1626851274 cites W1963725361 @default.
• W1626851274 cites W1964212105 @default.
• W1626851274 cites W1974355024 @default.
• W1626851274 cites W1989121777 @default.
• W1626851274 cites W1990005278 @default.
• W1626851274 cites W1991696233 @default.
• W1626851274 cites W1992178732 @default.
• W1626851274 cites W1996067072 @default.
• W1626851274 cites W2001255092 @default.
• W1626851274 cites W2005104372 @default.
• W1626851274 cites W2005662067 @default.
• W1626851274 cites W2005946375 @default.
• W1626851274 cites W2006865754 @default.
• W1626851274 cites W2009274826 @default.
• W1626851274 cites W2013302262 @default.
• W1626851274 cites W2026119866 @default.
• W1626851274 cites W2029587245 @default.
• W1626851274 cites W2036577816 @default.
• W1626851274 cites W2045048651 @default.
• W1626851274 cites W2053324328 @default.
• W1626851274 cites W2064641360 @default.
• W1626851274 cites W2066545172 @default.
• W1626851274 cites W2078119730 @default.
• W1626851274 cites W2081527075 @default.
• W1626851274 cites W2082378464 @default.
• W1626851274 cites W2086959949 @default.
• W1626851274 cites W2089883236 @default.
• W1626851274 cites W2109948920 @default.
• W1626851274 cites W2118863192 @default.
• W1626851274 cites W2125635172 @default.
• W1626851274 cites W2127081466 @default.
• W1626851274 cites W2134471382 @default.
• W1626851274 cites W2143824449 @default.
• W1626851274 cites W2144246125 @default.
• W1626851274 cites W2149793889 @default.
• W1626851274 cites W2150677022 @default.
• W1626851274 cites W2153056550 @default.
• W1626851274 cites W2158485828 @default.
• W1626851274 cites W2163544895 @default.
• W1626851274 cites W2164853531 @default.
• W1626851274 cites W2168303063 @default.
• W1626851274 cites W2170222791 @default.
• W1626851274 cites W2318738232 @default.
• W1626851274 doi "https://doi.org/10.1002/gcc.22160" @default.
• W1626851274 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24615732" @default.
• W1626851274 hasPublicationYear "2014" @default.
• W1626851274 type Work @default.
• W1626851274 sameAs 1626851274 @default.
• W1626851274 citedByCount "5" @default.
• W1626851274 countsByYear W16268512742015 @default.
• W1626851274 countsByYear W16268512742016 @default.
• W1626851274 countsByYear W16268512742017 @default.
• W1626851274 countsByYear W16268512742021 @default.
• W1626851274 crossrefType "journal-article" @default.
• W1626851274 hasAuthorship W1626851274A5002300255 @default.
• W1626851274 hasAuthorship W1626851274A5005052429 @default.
• W1626851274 hasAuthorship W1626851274A5007544895 @default.
• W1626851274 hasAuthorship W1626851274A5025742350 @default.
• W1626851274 hasAuthorship W1626851274A5027130762 @default.
• W1626851274 hasAuthorship W1626851274A5038081503 @default.
• W1626851274 hasAuthorship W1626851274A5039627791 @default.
• W1626851274 hasAuthorship W1626851274A5081257602 @default.
• W1626851274 hasAuthorship W1626851274A5085732836 @default.
• W1626851274 hasConcept C104317684 @default.
• W1626851274 hasConcept C120821319 @default.
• W1626851274 hasConcept C121608353 @default.
• W1626851274 hasConcept C124942203 @default.
• W1626851274 hasConcept C126322002 @default.
• W1626851274 hasConcept C141231307 @default.
• W1626851274 hasConcept C142724271 @default.
• W1626851274 hasConcept C143998085 @default.
• W1626851274 hasConcept C203014093 @default.
• W1626851274 hasConcept C2777658100 @default.
• W1626851274 hasConcept C2779013556 @default.
• W1626851274 hasConcept C2780283643 @default.
• W1626851274 hasConcept C2780849966 @default.
• W1626851274 hasConcept C502942594 @default.
• W1626851274 hasConcept C54355233 @default.
• W1626851274 hasConcept C71924100 @default.
• W1626851274 hasConcept C86803240 @default.

• next