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- W1627013485 abstract "Telaprevir is one of the first direct-acting antiviral drugs approved for the treatment of the hepatitis C virus (HCV) genotype 1. Following its approval in 2011, new data regarding the pharmacokinetics and pharmacodynamics were reported, leading to important clinical applications.This article reviews the pharmacokinetic and pharmacodynamic properties of telaprevir for the treatment of the HCV. The areas covered include data regarding the drug's absorption, distribution, metabolism and excretion, in addition to the antiviral activity strategy such as the clinical dose selection and treatment duration.Telaprevir presents several pharmacological properties that could limit its administration such a high-fat, high-calorie meal; the need to be administrated with pegylated IFN plus ribavirin; and the drug-drug interaction profile. As a consequence and considering the new therapeutic arsenal against the HCV, the use of telaprevir as part of HCV therapy will be limited." @default.
- W1627013485 created "2016-06-24" @default.
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- W1627013485 date "2015-05-25" @default.
- W1627013485 modified "2023-10-15" @default.
- W1627013485 title "Pharmacokinetic and pharmacodynamic evaluation of telaprevir for the treatment of hepatitis C" @default.
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- W1627013485 doi "https://doi.org/10.1517/17425255.2015.1049532" @default.
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