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- W162737098 abstract "Attempts to restore cholinergic deficits in Alzheimer’s disease patients involve the use of various drugs inhibiting cholinesterases (CHEs; Bartus et al., 1982). In addition, CHE inhibitors are clinically employed in the treatment of other common syndromes, including Parkinson’s disease, myasthenia gravis and multiple sclerosis (Taylor, 1990). The efficacy and specificity of such drugs on the one hand, and their toxicity factor on the other, largely depend on their inhibitory effects on CHEs in the treated individuals. Therefore, updated evaluation methods for these parameters should be valuable to pharmacological research focused on the development and use of cholinergic drugs." @default.
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- W162737098 date "1991-01-01" @default.
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- W162737098 title "Structure-Function Relationship Studies in Human Cholinesterases as an Approach for Evaluating Potential Pharmacotherapeutic and/Or Toxicity Effects of Cholinergic Drugs" @default.
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- W162737098 doi "https://doi.org/10.1007/978-1-4899-6738-1_5" @default.
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