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• W1627437536 abstract "Telomeres or nucleoprotein compounds are complexes that located at the ends of eukaryotic linear chromosomes and have many vital functions such as, protect the ends of chromosomes, complete replication of chromosome, a criterion for cell viability, and proper organization of chromosomes in the nucleus, regulate the expression of some genes and etc. During each cell division due to the end replication problem, continuously telomere length reduced which will be causes cell cycle arrest. Therefore telomeres as an internal controller clock set the number of cell divisions. Telomerase is a ribonucleoprotein enzyme with reverse transcription activity which adds DNA sequence repeats to the 3' end of DNA strands in the telomere regions can be solve this problem. About 90% of cancers cells are high telomerase activity that causes the cells immortalization. Unlike these cells, somatic cells are not very active. Therefore, analysis of telomerase activity in cancer cells can be detected as a tool for this purpose.Keywords: Telomere, TERT, Telomere Binding Proteins (TEBP), Telomerase Catalytic Subunit.," @default.
• W1627437536 created "2016-06-24" @default.
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• W1627437536 date "2013-04-15" @default.
• W1627437536 modified "2023-09-23" @default.
• W1627437536 title "Telomere, Chromosome End and Telomerase Enzyme as a Cancer Biomarker" @default.
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