Matches in SemOpenAlex for { <https://semopenalex.org/work/W1627667790> ?p ?o ?g. }
- W1627667790 abstract "Cancer cells have an altered metabolism that provides advantages to support unregulated growth and higher duplication rates. Among these critical changes, energy generation through aerobic glycolysis as well as increased glutamine catabolism, are essential components associated with altered levels of specific metabolites. Up-regulation of lipid metabolism also occurs frequently in cancer cells. Increased fatty-acid biosynthesis as well as their elongation and saturation processes are among widely recognized events that define cancer cells. Not surprisingly, the CDP-choline and CDP-ethanolamine pathways responsible for the generation of membrane phospholipids is a major alteration frequently found in human tumours. Choline kinase a (ChoKa) plays a critical role in this latter metabolic route and is the focus of a targeted therapeutic strategy. Small molecule inhibitors of this enzyme are effective and selective anticancer drugs that have recently entered clinical trials. More recently, ChoKa inhibitors have been proposed as a novel therapeutic approach against malaria and rheumatoid arthritis. Here, the evidence that support the use of ChoKa as a novel drug target for precision medicine approaches is discussed." @default.
- W1627667790 created "2016-06-24" @default.
- W1627667790 date "2015-10-27" @default.
- W1627667790 modified "2023-09-26" @default.
- W1627667790 title "CHOLINE KINASE AS A PRECISION MEDICINE TARGET FOR THERAPY IN CANCER, AUTOIMMUNE DISEASES AND MALARIA" @default.
- W1627667790 cites W1496167594 @default.
- W1627667790 cites W1503703432 @default.
- W1627667790 cites W1599985274 @default.
- W1627667790 cites W1705353203 @default.
- W1627667790 cites W1965954908 @default.
- W1627667790 cites W1968873370 @default.
- W1627667790 cites W1969743195 @default.
- W1627667790 cites W1970020398 @default.
- W1627667790 cites W1973640411 @default.
- W1627667790 cites W1974997269 @default.
- W1627667790 cites W1980180569 @default.
- W1627667790 cites W1984484754 @default.
- W1627667790 cites W1986094949 @default.
- W1627667790 cites W1991133712 @default.
- W1627667790 cites W1991761191 @default.
- W1627667790 cites W1994322821 @default.
- W1627667790 cites W1995138175 @default.
- W1627667790 cites W1996478052 @default.
- W1627667790 cites W1996536755 @default.
- W1627667790 cites W2001184953 @default.
- W1627667790 cites W2002759137 @default.
- W1627667790 cites W2006167699 @default.
- W1627667790 cites W2022009582 @default.
- W1627667790 cites W2022209028 @default.
- W1627667790 cites W2023714418 @default.
- W1627667790 cites W2023732704 @default.
- W1627667790 cites W2025342576 @default.
- W1627667790 cites W2028519621 @default.
- W1627667790 cites W2029053329 @default.
- W1627667790 cites W2033331422 @default.
- W1627667790 cites W2035625539 @default.
- W1627667790 cites W2037961777 @default.
- W1627667790 cites W2038092836 @default.
- W1627667790 cites W2039682439 @default.
- W1627667790 cites W2040246464 @default.
- W1627667790 cites W2041502679 @default.
- W1627667790 cites W2042619042 @default.
- W1627667790 cites W2044433401 @default.
- W1627667790 cites W2045851135 @default.
- W1627667790 cites W2055523684 @default.
- W1627667790 cites W2055614532 @default.
- W1627667790 cites W2057159445 @default.
- W1627667790 cites W2057408197 @default.
- W1627667790 cites W2059245628 @default.
- W1627667790 cites W2063052612 @default.
- W1627667790 cites W2065878600 @default.
- W1627667790 cites W2066492227 @default.
- W1627667790 cites W2066890145 @default.
- W1627667790 cites W2067929594 @default.
- W1627667790 cites W2072716779 @default.
- W1627667790 cites W2072860434 @default.
- W1627667790 cites W2073683003 @default.
- W1627667790 cites W2074438676 @default.
- W1627667790 cites W2083156321 @default.
- W1627667790 cites W2083166156 @default.
- W1627667790 cites W2085309285 @default.
- W1627667790 cites W2094402706 @default.
- W1627667790 cites W2097367553 @default.
- W1627667790 cites W2102782940 @default.
- W1627667790 cites W2103183938 @default.
- W1627667790 cites W2103994616 @default.
- W1627667790 cites W2106714630 @default.
- W1627667790 cites W2108462977 @default.
- W1627667790 cites W2110206765 @default.
- W1627667790 cites W2116722378 @default.
- W1627667790 cites W2117692326 @default.
- W1627667790 cites W2121651329 @default.
- W1627667790 cites W2123952137 @default.
- W1627667790 cites W2126361053 @default.
- W1627667790 cites W2127124052 @default.
- W1627667790 cites W2127537775 @default.
- W1627667790 cites W2129436739 @default.
- W1627667790 cites W2131837964 @default.
- W1627667790 cites W2143213077 @default.
- W1627667790 cites W2144332042 @default.
- W1627667790 cites W2144359625 @default.
- W1627667790 cites W2149121064 @default.
- W1627667790 cites W2153438036 @default.
- W1627667790 cites W2154129829 @default.
- W1627667790 cites W2154244078 @default.
- W1627667790 cites W2156233892 @default.
- W1627667790 cites W2156701124 @default.
- W1627667790 cites W2158640008 @default.
- W1627667790 cites W2164703295 @default.
- W1627667790 cites W2165048205 @default.
- W1627667790 cites W2165287714 @default.
- W1627667790 cites W2165995501 @default.
- W1627667790 cites W2169055028 @default.
- W1627667790 cites W2171466549 @default.
- W1627667790 cites W2173416403 @default.
- W1627667790 cites W2179379831 @default.
- W1627667790 cites W2312353293 @default.
- W1627667790 cites W2326487378 @default.
- W1627667790 cites W2330233053 @default.
- W1627667790 cites W2331521949 @default.