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• W162776871 abstract "In this study, we evaluated C-kit immunohistochemical expression and C-kit and platelet derived growth factor receptor A (PDGFRA) gene mutations in triple negative breast cancer. 171 cases were analyzed by immunohistochemical staining for the expression of C-kit and 45 cases, including 10 C-kit negative cases and 35 C-kit positive cases, were performed for C-kit gene mutations in exons 9, 11, 13 and 17 and PDGFRA gene mutations in exons 12 and 18. C-kit expression was detected in 42.1% of triple negative breast cancers. Only 1 activating mutation was detected in exon 11 of C-kit gene in 1 case. No activating mutations were found in the other 44 cases. C-kit expression is a frequent finding in triple negative breast cancers; 1 activating mutation which was also found in gastrointestinal stromal tumors was detected; a few cases might benefit from imatinib." @default.
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• W162776871 date "2014-01-01" @default.
• W162776871 modified "2023-09-23" @default.
• W162776871 title "C-kit and PDGFRA gene mutations in triple negative breast cancer." @default.
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• W162776871 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4129045" @default.
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