Matches in SemOpenAlex for { <https://semopenalex.org/work/W1627771650> ?p ?o ?g. }
- W1627771650 endingPage "3353" @default.
- W1627771650 startingPage "3346" @default.
- W1627771650 abstract "IL-12p35-deficient (IL-12p35(-/-)) mice were highly susceptible to Trypanosoma cruzi infection and succumbed during acute infection, demonstrating the crucial importance of endogenous IL-12 in resistance to experimental Chagas' disease. Delayed immune responses were observed in mutant mice, although comparable IFN-gamma and TNF-alpha blood levels as in wild-type mice were detected 2 wk postinfection. In vivo and in vitro analysis demonstrated that T cells, but not NK cells, were recruited to infected organs. Analysis of mice double deficient in the recombinase-activating gene 2 (RAG2) and IL-12p35, as well as studies involving T cell depletion, identified CD4(+) T cells as the cellular source for IL-12-independent IFN-gamma production. IL-18 was induced in IL-12p35(-/-) mice and was responsible for IFN-gamma production, as demonstrated by in vivo IL-18 neutralization studies. In conclusion, evidence is presented for an IL-12-independent IFN-gamma production in experimental Chagas' disease that is T cell and IL-18 dependent." @default.
- W1627771650 created "2016-06-24" @default.
- W1627771650 creator A5001325752 @default.
- W1627771650 creator A5004324305 @default.
- W1627771650 creator A5008489526 @default.
- W1627771650 creator A5010798008 @default.
- W1627771650 creator A5032817893 @default.
- W1627771650 creator A5048518247 @default.
- W1627771650 creator A5068754475 @default.
- W1627771650 creator A5080381047 @default.
- W1627771650 date "2001-09-15" @default.
- W1627771650 modified "2023-09-25" @default.
- W1627771650 title "IL-12-Independent IFN-γ Production by T Cells in Experimental Chagas’ Disease Is Mediated by IL-18" @default.
- W1627771650 cites W1535307867 @default.
- W1627771650 cites W1575726260 @default.
- W1627771650 cites W1767240058 @default.
- W1627771650 cites W1825265598 @default.
- W1627771650 cites W1853090825 @default.
- W1627771650 cites W1893523090 @default.
- W1627771650 cites W1905805852 @default.
- W1627771650 cites W1942672186 @default.
- W1627771650 cites W1949449831 @default.
- W1627771650 cites W1950868076 @default.
- W1627771650 cites W1979514172 @default.
- W1627771650 cites W1982213879 @default.
- W1627771650 cites W1983119957 @default.
- W1627771650 cites W1986814434 @default.
- W1627771650 cites W1994310347 @default.
- W1627771650 cites W1998477062 @default.
- W1627771650 cites W2002483968 @default.
- W1627771650 cites W2017684091 @default.
- W1627771650 cites W2018972324 @default.
- W1627771650 cites W2024581798 @default.
- W1627771650 cites W2026069714 @default.
- W1627771650 cites W2026161448 @default.
- W1627771650 cites W2028217729 @default.
- W1627771650 cites W2043400760 @default.
- W1627771650 cites W2057709277 @default.
- W1627771650 cites W2062472841 @default.
- W1627771650 cites W2062949290 @default.
- W1627771650 cites W2065550343 @default.
- W1627771650 cites W2072156556 @default.
- W1627771650 cites W2072652751 @default.
- W1627771650 cites W2080215877 @default.
- W1627771650 cites W2099048568 @default.
- W1627771650 cites W2106266051 @default.
- W1627771650 cites W2108473659 @default.
- W1627771650 cites W2112434543 @default.
- W1627771650 cites W2117166713 @default.
- W1627771650 cites W2122511642 @default.
- W1627771650 cites W2126464081 @default.
- W1627771650 cites W2135108170 @default.
- W1627771650 cites W2145200173 @default.
- W1627771650 cites W2146965501 @default.
- W1627771650 cites W2148088522 @default.
- W1627771650 cites W2154804530 @default.
- W1627771650 cites W2161305783 @default.
- W1627771650 cites W2161916137 @default.
- W1627771650 cites W2162451359 @default.
- W1627771650 cites W2170097211 @default.
- W1627771650 cites W2171231066 @default.
- W1627771650 cites W2171831396 @default.
- W1627771650 cites W2315827821 @default.
- W1627771650 cites W4313347710 @default.
- W1627771650 doi "https://doi.org/10.4049/jimmunol.167.6.3346" @default.
- W1627771650 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11544324" @default.
- W1627771650 hasPublicationYear "2001" @default.
- W1627771650 type Work @default.
- W1627771650 sameAs 1627771650 @default.
- W1627771650 citedByCount "94" @default.
- W1627771650 countsByYear W16277716502012 @default.
- W1627771650 countsByYear W16277716502013 @default.
- W1627771650 countsByYear W16277716502014 @default.
- W1627771650 countsByYear W16277716502015 @default.
- W1627771650 countsByYear W16277716502016 @default.
- W1627771650 countsByYear W16277716502017 @default.
- W1627771650 countsByYear W16277716502018 @default.
- W1627771650 countsByYear W16277716502019 @default.
- W1627771650 countsByYear W16277716502020 @default.
- W1627771650 countsByYear W16277716502021 @default.
- W1627771650 crossrefType "journal-article" @default.
- W1627771650 hasAuthorship W1627771650A5001325752 @default.
- W1627771650 hasAuthorship W1627771650A5004324305 @default.
- W1627771650 hasAuthorship W1627771650A5008489526 @default.
- W1627771650 hasAuthorship W1627771650A5010798008 @default.
- W1627771650 hasAuthorship W1627771650A5032817893 @default.
- W1627771650 hasAuthorship W1627771650A5048518247 @default.
- W1627771650 hasAuthorship W1627771650A5068754475 @default.
- W1627771650 hasAuthorship W1627771650A5080381047 @default.
- W1627771650 hasBestOaLocation W16277716501 @default.
- W1627771650 hasConcept C112418997 @default.
- W1627771650 hasConcept C134018914 @default.
- W1627771650 hasConcept C136764020 @default.
- W1627771650 hasConcept C149532602 @default.
- W1627771650 hasConcept C150903083 @default.
- W1627771650 hasConcept C153911025 @default.
- W1627771650 hasConcept C154317977 @default.
- W1627771650 hasConcept C159047783 @default.