FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W162795330> ?p ?o ?g. }

• W162795330 endingPage "1844" @default.
• W162795330 startingPage "1839" @default.
• W162795330 abstract "A 20-residue hybrid peptide CA(1-8)-MA(1-12) (CAMA) incorporating residues 1-8 of cecropin A (CA) and residues 1-12 of magainin 2 (MA) has high antimicrobial activity without toxicity. To investigate the effects of the total positive charges of CAMA on the antibacterial activity and toxicity, a hybrid peptide analogue (CAMA-syn) was designed with substitutions of <TEX>$Ile^{10};and;Ser^{16}$</TEX> with Lys. According to CD spectra, structure of CAMA-syn with increase of cationicity was very similar to that of CAMA in DPC micelle. CAMA-syn showed antimicrobial activity similar with CAMA while CAMA-syn has no hemolytic activity and much lower cytotoxicity against RAW 264.7 macrophage cells than CAMA. Also, CAMA and CAMA-syn significantly inhibited NO production by LPSstimulated RAW264.7 macrophage at 10.0∼20.0 <TEX>$mu$</TEX>M. CAMA-syn displayed salt resistance on antimicrobial activity against Escherichia coli at the physiological concentrations of <TEX>$CaCl_2;and;MgCl_2$</TEX>. The combination studies of peptides and antibiotics showed that CAMA-syn has synergistic effects with synthetic compound and flavonoid against Enterococcus faecalis and VREF. CAMA-syn can be a good candidate for the development of new antibiotics with potent antibacterial and synergistic activity but without cytotoxicity." @default.
• W162795330 created "2016-06-24" @default.
• W162795330 date "2009-08-20" @default.
• W162795330 modified "2023-10-18" @default.
• W162795330 title "Antibacterial Activity and Synergism of the Hybrid Antimicrobial Peptide, CAMA-syn" @default.
• W162795330 cites W163613073 @default.
• W162795330 cites W1916702144 @default.
• W162795330 cites W1970197942 @default.
• W162795330 cites W1970621669 @default.
• W162795330 cites W1974164511 @default.
• W162795330 cites W1981531829 @default.
• W162795330 cites W1990802251 @default.
• W162795330 cites W1991081822 @default.
• W162795330 cites W1997560226 @default.
• W162795330 cites W2002066211 @default.
• W162795330 cites W2003318145 @default.
• W162795330 cites W2003493354 @default.
• W162795330 cites W2007807255 @default.
• W162795330 cites W2008823647 @default.
• W162795330 cites W2016562927 @default.
• W162795330 cites W2017709657 @default.
• W162795330 cites W2027592088 @default.
• W162795330 cites W2047887742 @default.
• W162795330 cites W2053418558 @default.
• W162795330 cites W2070419861 @default.
• W162795330 cites W2078742168 @default.
• W162795330 cites W2079468421 @default.
• W162795330 cites W2092981599 @default.
• W162795330 cites W2097098774 @default.
• W162795330 cites W2111839343 @default.
• W162795330 cites W2130974803 @default.
• W162795330 cites W2134715100 @default.
• W162795330 cites W2135499146 @default.
• W162795330 cites W2143224430 @default.
• W162795330 cites W2163251457 @default.
• W162795330 cites W2952482091 @default.
• W162795330 cites W4255507877 @default.
• W162795330 cites W792968022 @default.
• W162795330 doi "https://doi.org/10.5012/bkcs.2009.30.8.1839" @default.
• W162795330 hasPublicationYear "2009" @default.
• W162795330 type Work @default.
• W162795330 sameAs 162795330 @default.
• W162795330 citedByCount "10" @default.
• W162795330 countsByYear W1627953302012 @default.
• W162795330 countsByYear W1627953302014 @default.
• W162795330 countsByYear W1627953302016 @default.
• W162795330 countsByYear W1627953302017 @default.
• W162795330 countsByYear W1627953302019 @default.
• W162795330 countsByYear W1627953302020 @default.
• W162795330 crossrefType "journal-article" @default.
• W162795330 hasBestOaLocation W1627953301 @default.
• W162795330 hasConcept C104317684 @default.
• W162795330 hasConcept C109316439 @default.
• W162795330 hasConcept C178790620 @default.
• W162795330 hasConcept C185592680 @default.
• W162795330 hasConcept C202751555 @default.
• W162795330 hasConcept C2778553168 @default.
• W162795330 hasConcept C2779281246 @default.
• W162795330 hasConcept C2779895986 @default.
• W162795330 hasConcept C2780104969 @default.
• W162795330 hasConcept C4937899 @default.
• W162795330 hasConcept C523546767 @default.
• W162795330 hasConcept C540938839 @default.
• W162795330 hasConcept C54355233 @default.
• W162795330 hasConcept C547475151 @default.
• W162795330 hasConcept C55493867 @default.
• W162795330 hasConcept C86803240 @default.
• W162795330 hasConceptScore W162795330C104317684 @default.
• W162795330 hasConceptScore W162795330C109316439 @default.
• W162795330 hasConceptScore W162795330C178790620 @default.
• W162795330 hasConceptScore W162795330C185592680 @default.
• W162795330 hasConceptScore W162795330C202751555 @default.
• W162795330 hasConceptScore W162795330C2778553168 @default.
• W162795330 hasConceptScore W162795330C2779281246 @default.
• W162795330 hasConceptScore W162795330C2779895986 @default.
• W162795330 hasConceptScore W162795330C2780104969 @default.
• W162795330 hasConceptScore W162795330C4937899 @default.
• W162795330 hasConceptScore W162795330C523546767 @default.
• W162795330 hasConceptScore W162795330C540938839 @default.
• W162795330 hasConceptScore W162795330C54355233 @default.
• W162795330 hasConceptScore W162795330C547475151 @default.
• W162795330 hasConceptScore W162795330C55493867 @default.
• W162795330 hasConceptScore W162795330C86803240 @default.
• W162795330 hasIssue "8" @default.
• W162795330 hasLocation W1627953301 @default.
• W162795330 hasOpenAccess W162795330 @default.
• W162795330 hasPrimaryLocation W1627953301 @default.
• W162795330 hasRelatedWork W1504260612 @default.
• W162795330 hasRelatedWork W2057260966 @default.
• W162795330 hasRelatedWork W2066212204 @default.
• W162795330 hasRelatedWork W2624333686 @default.
• W162795330 hasRelatedWork W2791327414 @default.
• W162795330 hasRelatedWork W2944339575 @default.
• W162795330 hasRelatedWork W3116022174 @default.
• W162795330 hasRelatedWork W4205316084 @default.
• W162795330 hasRelatedWork W4206981172 @default.
• W162795330 hasRelatedWork W4285084116 @default.
• W162795330 hasVolume "30" @default.

• next