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• W1628125917 abstract "Intracellular Ca 2+ (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M1><mml:mrow><mml:msub><mml:mrow><mml:mtext>[</mml:mtext><mml:msup><mml:mrow><mml:mtext>Ca</mml:mtext></mml:mrow><mml:mrow><mml:mtext>2+</mml:mtext></mml:mrow></mml:msup><mml:mtext>]</mml:mtext></mml:mrow><mml:mrow><mml:mi>i</mml:mi></mml:mrow></mml:msub></mml:mrow></mml:math>) is platelet aggregation-inducing molecule and is involved in activation of aggregation associated molecules. This study was carried out to understand the Ca 2+ -antagonistic effect of ginsenoside Ro (G-Ro), an oleanane-type saponin in Panax ginseng . G-Ro, without affecting leakage of lactate dehydrogenase, dose-dependently inhibited thrombin-induced platelet aggregation, and the half maximal inhibitory concentration was approximately 155 μ M. G-Ro inhibited strongly thrombin-elevated<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M2><mml:mrow><mml:msub><mml:mrow><mml:mtext>[</mml:mtext><mml:msup><mml:mrow><mml:mtext>Ca</mml:mtext></mml:mrow><mml:mrow><mml:mtext>2+</mml:mtext></mml:mrow></mml:msup><mml:mtext>]</mml:mtext></mml:mrow><mml:mrow><mml:mi>i</mml:mi></mml:mrow></mml:msub></mml:mrow></mml:math>, which was strongly increased by A-kinase inhibitor Rp-8-Br-cAMPS compared to G-kinase inhibitor Rp-8-Br-cGMPS. G-Ro increased the level of cAMP and subsequently elevated the phosphorylation of inositol 1, 4, 5-triphosphate receptor I (IP 3 RI) (Ser 1756 ) to inhibit<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M3><mml:mrow><mml:msub><mml:mrow><mml:mtext>[</mml:mtext><mml:msup><mml:mrow><mml:mtext>Ca</mml:mtext></mml:mrow><mml:mrow><mml:mtext>2+</mml:mtext></mml:mrow></mml:msup><mml:mtext>]</mml:mtext></mml:mrow><mml:mrow><mml:mi>i</mml:mi></mml:mrow></mml:msub></mml:mrow></mml:math>mobilization in thrombin-induced platelet aggregation. Phosphorylation of IP 3 RI (Ser 1756 ) by G-Ro was decreased by PKA inhibitor Rp-8-Br-cAMPS. In addition, G-Ro inhibited thrombin-induced phosphorylation of ERK 2 (42 kDa), indicating inhibition of Ca 2+ influx across plasma membrane. We demonstrate that G-Ro upregulates cAMP-dependent IP 3 RI (Ser 1756 ) phosphorylation and downregulates phosphorylation of ERK 2 (42 kDa) to decrease thrombin-elevated<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M4><mml:mrow><mml:msub><mml:mrow><mml:mtext>[</mml:mtext><mml:msup><mml:mrow><mml:mtext>Ca</mml:mtext></mml:mrow><mml:mrow><mml:mtext>2+</mml:mtext></mml:mrow></mml:msup><mml:mtext>]</mml:mtext></mml:mrow><mml:mrow><mml:mi>i</mml:mi></mml:mrow></mml:msub></mml:mrow></mml:math>, which contributes to inhibition of ATP and serotonin release, and p-selectin expression. These results indicate that G-Ro in Panax ginseng is a beneficial novel Ca 2+ -antagonistic compound and may prevent platelet aggregation-mediated thrombotic disease." @default.
• W1628125917 created "2016-06-24" @default.
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• W1628125917 date "2015-01-01" @default.
• W1628125917 modified "2023-10-16" @default.
• W1628125917 title "Inhibitory Effects of Cytosolic Ca²⁺Concentration by Ginsenoside Ro Are Dependent on Phosphorylation of IP₃RI and Dephosphorylation of ERK in Human Platelets" @default.
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• W1628125917 doi "https://doi.org/10.1155/2015/764906" @default.
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