FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W162815948> ?p ?o ?g. }

• W162815948 endingPage "9" @default.
• W162815948 startingPage "25" @default.
• W162815948 abstract "One of the main obstacles in pharmaceutical applications of cyclodextrins is their increase of the formulation bulk. Even at maximum incorporation 500 mg of a solid drug/cyclodextrin complex will only contain between 50 and 125 mg of the drug, assuming a low molecular weight drug (MW 200 to 400 Dalton) and an average molecular weight cyclodextrin (MW about 1500 Dalton). In general, the complexation efficiency is low and consequently the complex powder contains a significant amount of empty cyclodextrin molecules. In the present study the complexation efficiency is increased by ionization of the drug molecule through addition of volatile acid (i.e. acetic acid) or base (i.e. ammonia) to the aqueous complexation media of basic or acidic drugs, respectively. The volatile acid or base was then removed during lyophilization and heating in a vacuum oven resulting in formation of solid cyclodextrin complexes of the unionized drug. Thus, the complexation efficiency was temporary increased by the ionization but then again decreased leading to formation of the thermodynamically unstable solid drug/cyclodextrin complexes. When dissolved the energy of the system was lowered by expelling the drug molecules from the cyclodextrin cavities resulting in formation of supersaturated drug solutions and ultimately precipitation of the drug." @default.
• W162815948 created "2016-06-24" @default.
• W162815948 creator A5000344770 @default.
• W162815948 creator A5010526934 @default.
• W162815948 creator A5062520026 @default.
• W162815948 creator A5088436532 @default.
• W162815948 date "2004-01-01" @default.
• W162815948 modified "2023-09-28" @default.
• W162815948 title "Preparation of solid drug/cyclodextrin complexes of acidic and basic drugs." @default.
• W162815948 cites W1521423841 @default.
• W162815948 cites W183429264 @default.
• W162815948 cites W2003080384 @default.
• W162815948 cites W2019021446 @default.
• W162815948 cites W2023886434 @default.
• W162815948 cites W2024048542 @default.
• W162815948 cites W2038186172 @default.
• W162815948 cites W2046017608 @default.
• W162815948 cites W2064135629 @default.
• W162815948 cites W2075268393 @default.
• W162815948 cites W2090075684 @default.
• W162815948 cites W2093348832 @default.
• W162815948 cites W2096321754 @default.
• W162815948 cites W2169315622 @default.
• W162815948 cites W2405627046 @default.
• W162815948 cites W2408045947 @default.
• W162815948 cites W2425618955 @default.
• W162815948 cites W268671444 @default.
• W162815948 cites W287828772 @default.
• W162815948 cites W2951491910 @default.
• W162815948 cites W33792546 @default.
• W162815948 cites W2485778548 @default.
• W162815948 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14964417" @default.
• W162815948 hasPublicationYear "2004" @default.
• W162815948 type Work @default.
• W162815948 sameAs 162815948 @default.
• W162815948 citedByCount "12" @default.
• W162815948 countsByYear W1628159482013 @default.
• W162815948 countsByYear W1628159482014 @default.
• W162815948 countsByYear W1628159482023 @default.
• W162815948 crossrefType "journal-article" @default.
• W162815948 hasAuthorship W162815948A5000344770 @default.
• W162815948 hasAuthorship W162815948A5010526934 @default.
• W162815948 hasAuthorship W162815948A5062520026 @default.
• W162815948 hasAuthorship W162815948A5088436532 @default.
• W162815948 hasConcept C107054158 @default.
• W162815948 hasConcept C118552586 @default.
• W162815948 hasConcept C121332964 @default.
• W162815948 hasConcept C13965031 @default.
• W162815948 hasConcept C153294291 @default.
• W162815948 hasConcept C155574463 @default.
• W162815948 hasConcept C15744967 @default.
• W162815948 hasConcept C178790620 @default.
• W162815948 hasConcept C184651966 @default.
• W162815948 hasConcept C185592680 @default.
• W162815948 hasConcept C200447597 @default.
• W162815948 hasConcept C2776382133 @default.
• W162815948 hasConcept C2776673659 @default.
• W162815948 hasConcept C2778649806 @default.
• W162815948 hasConcept C2779433975 @default.
• W162815948 hasConcept C2780035454 @default.
• W162815948 hasConcept C32909587 @default.
• W162815948 hasConcept C43617362 @default.
• W162815948 hasConceptScore W162815948C107054158 @default.
• W162815948 hasConceptScore W162815948C118552586 @default.
• W162815948 hasConceptScore W162815948C121332964 @default.
• W162815948 hasConceptScore W162815948C13965031 @default.
• W162815948 hasConceptScore W162815948C153294291 @default.
• W162815948 hasConceptScore W162815948C155574463 @default.
• W162815948 hasConceptScore W162815948C15744967 @default.
• W162815948 hasConceptScore W162815948C178790620 @default.
• W162815948 hasConceptScore W162815948C184651966 @default.
• W162815948 hasConceptScore W162815948C185592680 @default.
• W162815948 hasConceptScore W162815948C200447597 @default.
• W162815948 hasConceptScore W162815948C2776382133 @default.
• W162815948 hasConceptScore W162815948C2776673659 @default.
• W162815948 hasConceptScore W162815948C2778649806 @default.
• W162815948 hasConceptScore W162815948C2779433975 @default.
• W162815948 hasConceptScore W162815948C2780035454 @default.
• W162815948 hasConceptScore W162815948C32909587 @default.
• W162815948 hasConceptScore W162815948C43617362 @default.
• W162815948 hasIssue "1" @default.
• W162815948 hasLocation W1628159481 @default.
• W162815948 hasOpenAccess W162815948 @default.
• W162815948 hasPrimaryLocation W1628159481 @default.
• W162815948 hasRelatedWork W1605105871 @default.
• W162815948 hasRelatedWork W2016220827 @default.
• W162815948 hasRelatedWork W2018066854 @default.
• W162815948 hasRelatedWork W2040242287 @default.
• W162815948 hasRelatedWork W2080415635 @default.
• W162815948 hasRelatedWork W2086382785 @default.
• W162815948 hasRelatedWork W2135607174 @default.
• W162815948 hasRelatedWork W2138197143 @default.
• W162815948 hasRelatedWork W2392191690 @default.
• W162815948 hasRelatedWork W465438923 @default.
• W162815948 hasVolume "59" @default.
• W162815948 isParatext "false" @default.
• W162815948 isRetracted "false" @default.
• W162815948 magId "162815948" @default.

• next