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- W1628370030 abstract "OBJECTIVE: To explore the association between asymptomatic intermittent temporal slowing and longitudinal cognitive performance in the oldest-old, people aged 90 and over.BACKGROUND: In routine clinical practice, intermittent temporal slowing (ITS) is associated with focal cerebral lesions such as stroke or head trauma, which are also associated with cognitive impairment. In contrast, ITS is highly prevalent (>50%) in cognitively intact elderly (蠅85 years old) without any history of seizure, stroke or head trauma. The consequence of ITS is unclear as the current literature lacks longitudinal cognitive evaluations of the very elderly with asymptomatic ITS.METHODS: We evaluated 12 participants from The 90+ Study, a population based investigation of people aged 90 and older. We obtained 1-hour Standard International 10-20 System EEG within 3 months of baseline neuropsychological testing repeated every 6 months. Tests included measures of global cognition (MMSE), memory (CVLT long-delay) and language (animal fluency). Average rate of change in cognitive scores was compared in participants with (n=8) and without (n=4) ITS.RESULTS: At baseline, all participants were cognitively normal (mean MMSE: 29 (range:26-30)), mostly women (67%) with an average age of 94 years (range:91-99). The average length of follow-up was 4 years (range:1.1-4.5). We saw no difference in the average annual rate of decline in participants with and without ITS on MMSE (0.64 vs. 0.33points/year, t=0.51, p=0.62), CVLT long-delay (0.07 vs. 0.53points/year, t=1.86, p=0.10), and animal fluency (0.22 vs. 0.20points/year, t=0.05, p=0.96). One person with ITS developed dementia.CONCLUSIONS: In this preliminary study, asymptomatic ITS was not associated with subsequent cognitive decline in healthy oldest-old participants. ITS may represent a benign, aging phenomenon, as opposed to an underlying pathological process, and may not require further clinical work-up in the oldest-old. However, the small sample size limits our statistical power and the results warrant a larger study to confirm the findings.Study supported by: NIH grants T32NS045540 and R01AG21055 Disclosure: Dr. Bullain has nothing to disclose. Dr. Corrada has nothing to disclose. Dr. Greenia has nothing to disclose. Dr. Kawas has received personal compensation for activities with Biogen Idec. Dr. Kawas has received personal compensation in an editorial capacity for Continuum." @default.
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- W1628370030 date "2014-04-08" @default.
- W1628370030 modified "2023-09-24" @default.
- W1628370030 title "Intermittent Temporal Slowing in Cognitively Normal Oldest-old: The 90+ EEG Study (P3.214)" @default.
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