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• W1628441491 abstract "Expanded CD4(+)CD28(null) T cells have not been described in the circulation of patients with chronic hepatitis B (CHB). The aim of the present was to detect and characterize the surface phenotype and functional capacity of these cells in CHB patients. Expanded CD4(+)CD28(null) T cells were detected in the circulation of CHB patients with high viral load and elevated aminotransferase levels. Most CD4(+)CD28(null) T cells showed a CD27-CD45RA(-)CD45RO(+) surface phenotype. The markers CD56, CD57 and killer immunoglobulin-like receptor (KIR) were detected on CD4(+)CD28(null) T cells, but the majority were positive for CD57. Functionally, CD4(+)CD28(null) T cells were found to be potent cytotoxic T lymphocytes with perforin and granzyme B secretion profiles. These findings indicate that the expanded CD4(+)CD28(null) T cells are cytotoxic memory T cells and display a distinct functional phenotype in comparison with CD4(+)CD28(+) T cells. The presence of these cells appears to be associated with inflammatory conditions, suggesting that these elevated CD4(+)CD28(null) T cells might be involved in the pathogenesis of CHB." @default.
• W1628441491 created "2016-06-24" @default.
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• W1628441491 date "2009-01-01" @default.
• W1628441491 modified "2023-10-02" @default.
• W1628441491 title "Characteristics of Expanded CD4⁺CD28^nullT Cells in Patients with Chronic Hepatitis B" @default.
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• W1628441491 doi "https://doi.org/10.1080/08820130902943105" @default.
• W1628441491 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19811419" @default.
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