FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1628761409> ?p ?o ?g. }

• W1628761409 endingPage "132" @default.
• W1628761409 startingPage "126" @default.
• W1628761409 abstract "Fat embolism syndrome (FES) is a common complication of long bone fractures. FES is rare but with significant morbidity and occasional fatalities. Studies of animal models of FES are numerous; however, few studies compare inflammatory reactions in multiple organs. The present study investigated the effect of neutral fat and fatty acids, which cause changes in multiple organs and induce FES. Using rats we evaluated the ratio of lung-to-body weight and conducted histological analyses and quantitative analysis of inflammatory cytokine mRNAs in the lungs following intravenous administration of neutral fat or fatty acids. Neutral fat increased the ratio of lung-to-body weight, and neutral fat formed emboli in lung capillaries. The levels of interleukin-1 beta (IL-1β), IL-6 and tumor necrosis factor-alpha (TNF-α) in the lungs increased after injection of neutral fat and oleic acid. Analysis of the histologic changes revealed that the highest numbers of fat droplets, occluding the capillaries of the lungs, kidney, heart, and brain formed 12h after the injection of neutral fat and fat droplets gradually diminished 48h later. Fat droplets were not detected in any organs after the injection of oleic acid. IL-1β and TNF-α levels in the lungs were elevated 9-24h after the injection of neutral fat, although IL-6 levels peaked at 6h. After injection of oleic acid, peak levels of IL-1β, IL-6, and TNF-α were detected at 6h, and IL-6 again increased in all organs and plasma at 15h. Neutral fat, but not fatty acids, formed emboli in the capillaries of multiple organs. These findings suggest that neutral fat increased inflammatory cytokine levels by forming emboli in organ capillaries, particularly in the lungs, while oleic acid augmented inflammatory cytokine levels by stimulating endothelial cells of multiple organs." @default.
• W1628761409 created "2016-06-24" @default.
• W1628761409 creator A5015826922 @default.
• W1628761409 creator A5018976651 @default.
• W1628761409 creator A5022828891 @default.
• W1628761409 creator A5033707276 @default.
• W1628761409 creator A5040377584 @default.
• W1628761409 creator A5044694904 @default.
• W1628761409 creator A5045310248 @default.
• W1628761409 creator A5047149453 @default.
• W1628761409 creator A5051884513 @default.
• W1628761409 creator A5064125169 @default.
• W1628761409 date "2015-09-01" @default.
• W1628761409 modified "2023-09-24" @default.
• W1628761409 title "Inflammatory responses to neutral fat and fatty acids in multiple organs in a rat model of fat embolism syndrome" @default.
• W1628761409 cites W1970362472 @default.
• W1628761409 cites W1973510955 @default.
• W1628761409 cites W1976252038 @default.
• W1628761409 cites W1984438070 @default.
• W1628761409 cites W1998503487 @default.
• W1628761409 cites W2012272510 @default.
• W1628761409 cites W2038866449 @default.
• W1628761409 cites W2051420025 @default.
• W1628761409 cites W2052080794 @default.
• W1628761409 cites W2064309187 @default.
• W1628761409 cites W2067613277 @default.
• W1628761409 cites W2071117491 @default.
• W1628761409 cites W2073701864 @default.
• W1628761409 cites W2076964633 @default.
• W1628761409 cites W2080767539 @default.
• W1628761409 cites W2086840459 @default.
• W1628761409 cites W2088092566 @default.
• W1628761409 cites W2088220499 @default.
• W1628761409 cites W2097698172 @default.
• W1628761409 cites W2098288995 @default.
• W1628761409 cites W2133994476 @default.
• W1628761409 cites W2152429535 @default.
• W1628761409 cites W2155574689 @default.
• W1628761409 cites W2159200533 @default.
• W1628761409 cites W2161318915 @default.
• W1628761409 cites W2306841939 @default.
• W1628761409 cites W2326595738 @default.
• W1628761409 cites W3088413244 @default.
• W1628761409 cites W4240234044 @default.
• W1628761409 doi "https://doi.org/10.1016/j.forsciint.2015.07.011" @default.
• W1628761409 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26218407" @default.
• W1628761409 hasPublicationYear "2015" @default.
• W1628761409 type Work @default.
• W1628761409 sameAs 1628761409 @default.
• W1628761409 citedByCount "13" @default.
• W1628761409 countsByYear W16287614092016 @default.
• W1628761409 countsByYear W16287614092017 @default.
• W1628761409 countsByYear W16287614092018 @default.
• W1628761409 countsByYear W16287614092019 @default.
• W1628761409 countsByYear W16287614092020 @default.
• W1628761409 countsByYear W16287614092021 @default.
• W1628761409 countsByYear W16287614092022 @default.
• W1628761409 countsByYear W16287614092023 @default.
• W1628761409 crossrefType "journal-article" @default.
• W1628761409 hasAuthorship W1628761409A5015826922 @default.
• W1628761409 hasAuthorship W1628761409A5018976651 @default.
• W1628761409 hasAuthorship W1628761409A5022828891 @default.
• W1628761409 hasAuthorship W1628761409A5033707276 @default.
• W1628761409 hasAuthorship W1628761409A5040377584 @default.
• W1628761409 hasAuthorship W1628761409A5044694904 @default.
• W1628761409 hasAuthorship W1628761409A5045310248 @default.
• W1628761409 hasAuthorship W1628761409A5047149453 @default.
• W1628761409 hasAuthorship W1628761409A5051884513 @default.
• W1628761409 hasAuthorship W1628761409A5064125169 @default.
• W1628761409 hasConcept C126322002 @default.
• W1628761409 hasConcept C134018914 @default.
• W1628761409 hasConcept C142724271 @default.
• W1628761409 hasConcept C185592680 @default.
• W1628761409 hasConcept C2777714996 @default.
• W1628761409 hasConcept C2778298768 @default.
• W1628761409 hasConcept C2780091579 @default.
• W1628761409 hasConcept C2781403372 @default.
• W1628761409 hasConcept C543025807 @default.
• W1628761409 hasConcept C55493867 @default.
• W1628761409 hasConcept C71924100 @default.
• W1628761409 hasConceptScore W1628761409C126322002 @default.
• W1628761409 hasConceptScore W1628761409C134018914 @default.
• W1628761409 hasConceptScore W1628761409C142724271 @default.
• W1628761409 hasConceptScore W1628761409C185592680 @default.
• W1628761409 hasConceptScore W1628761409C2777714996 @default.
• W1628761409 hasConceptScore W1628761409C2778298768 @default.
• W1628761409 hasConceptScore W1628761409C2780091579 @default.
• W1628761409 hasConceptScore W1628761409C2781403372 @default.
• W1628761409 hasConceptScore W1628761409C543025807 @default.
• W1628761409 hasConceptScore W1628761409C55493867 @default.
• W1628761409 hasConceptScore W1628761409C71924100 @default.
• W1628761409 hasLocation W16287614091 @default.
• W1628761409 hasLocation W16287614092 @default.
• W1628761409 hasOpenAccess W1628761409 @default.
• W1628761409 hasPrimaryLocation W16287614091 @default.
• W1628761409 hasRelatedWork W2042033030 @default.
• W1628761409 hasRelatedWork W2048039626 @default.
• W1628761409 hasRelatedWork W2070511355 @default.

• next