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• W162907728 abstract "One of the most pressing issues facing the pharmaceutical and biotechnology industry is the tremendous dropout rate of lead drug candidates. Over the last two decades, several new genomic technologies have been developed in hopes of addressing the issues of target identification and lead candidate optimization. Gene expression microarray is one of these technologies and this review describes the four main formats, which are currently available: (a) cDNA; (b) oligonucleotide; (c) electrokinetic; and (d) fiberoptic. Many of these formats have been developed with the goal of screening large numbers of genes. Recently, a high-throughput array format has been developed where a large number of samples can be assayed using arrays in parallel. In addition, focusing on gene expression may be only one avenue in preventing lead candidate failure. Proteomics or the study of protein expression may also play a role. Two-dimensional polyacrylamide gel electrophoresis (2-DE) coupled with mass spectroscopy has been the most widely accepted format to study protein expression. However, protein microarrays are now being developed and modified to a high-throughput screening format. Examples of several gene and protein expression studies as they apply to drug discovery and development are reviewed. These studies often result in large data sets. Examples of how several statistical methods (principal components analysis [PCA], clustering methods, Shannon entropy, etc.) have been applied to these data sets are also described. These newer genomic and proteomic technologies and their analysis and visualization methods have the potential to make the drug discovery and development process less costly and more efficient by aiding to select better target and lead candidates." @default.
• W162907728 created "2016-06-24" @default.
• W162907728 creator A5067032995 @default.
• W162907728 date "2000-07-01" @default.
• W162907728 modified "2023-10-02" @default.
• W162907728 title "Genomics and proteomics" @default.
• W162907728 cites W1583683345 @default.
• W162907728 cites W1584900133 @default.
• W162907728 cites W1606423922 @default.
• W162907728 cites W1651215666 @default.
• W162907728 cites W1967997384 @default.
• W162907728 cites W1968049281 @default.
• W162907728 cites W1968828650 @default.
• W162907728 cites W1970156673 @default.
• W162907728 cites W1972113680 @default.
• W162907728 cites W1974449666 @default.
• W162907728 cites W1974830441 @default.
• W162907728 cites W1975188059 @default.
• W162907728 cites W1977664347 @default.
• W162907728 cites W1978368163 @default.
• W162907728 cites W1978943629 @default.
• W162907728 cites W1980094946 @default.
• W162907728 cites W1985080632 @default.
• W162907728 cites W1985423817 @default.
• W162907728 cites W1986088012 @default.
• W162907728 cites W1988894809 @default.
• W162907728 cites W1989297334 @default.
• W162907728 cites W1991761877 @default.
• W162907728 cites W1994098923 @default.
• W162907728 cites W1995049704 @default.
• W162907728 cites W1995382459 @default.
• W162907728 cites W1995806138 @default.
• W162907728 cites W1998251495 @default.
• W162907728 cites W2000334423 @default.
• W162907728 cites W2001526641 @default.
• W162907728 cites W2002046224 @default.
• W162907728 cites W2005453259 @default.
• W162907728 cites W2006774455 @default.
• W162907728 cites W2009858427 @default.
• W162907728 cites W2012878989 @default.
• W162907728 cites W2013596633 @default.
• W162907728 cites W2016799976 @default.
• W162907728 cites W2017914938 @default.
• W162907728 cites W2018066428 @default.
• W162907728 cites W2018843280 @default.
• W162907728 cites W2021606973 @default.
• W162907728 cites W2021824829 @default.
• W162907728 cites W2022227920 @default.
• W162907728 cites W2027590165 @default.
• W162907728 cites W2030958510 @default.
• W162907728 cites W2033333170 @default.
• W162907728 cites W2037509330 @default.
• W162907728 cites W2038636949 @default.
• W162907728 cites W2038997703 @default.
• W162907728 cites W2043754674 @default.
• W162907728 cites W2043981588 @default.
• W162907728 cites W2049779595 @default.
• W162907728 cites W2056447265 @default.
• W162907728 cites W2059667789 @default.
• W162907728 cites W2063124307 @default.
• W162907728 cites W2063790852 @default.
• W162907728 cites W2069271664 @default.
• W162907728 cites W2072069835 @default.
• W162907728 cites W2074064799 @default.
• W162907728 cites W2075139148 @default.
• W162907728 cites W2077077811 @default.
• W162907728 cites W2077095651 @default.
• W162907728 cites W2081249438 @default.
• W162907728 cites W2086907176 @default.
• W162907728 cites W2087684630 @default.
• W162907728 cites W2093009120 @default.
• W162907728 cites W2096071379 @default.
• W162907728 cites W2097981550 @default.
• W162907728 cites W2098132781 @default.
• W162907728 cites W2098314636 @default.
• W162907728 cites W2098357168 @default.
• W162907728 cites W2099373511 @default.
• W162907728 cites W2101455212 @default.
• W162907728 cites W2101904615 @default.
• W162907728 cites W2102794349 @default.
• W162907728 cites W2103486316 @default.
• W162907728 cites W2109363337 @default.
• W162907728 cites W2113310577 @default.
• W162907728 cites W2114454856 @default.
• W162907728 cites W2115759544 @default.
• W162907728 cites W2118577784 @default.
• W162907728 cites W2119265707 @default.
• W162907728 cites W2129200287 @default.
• W162907728 cites W2133241531 @default.
• W162907728 cites W2133404189 @default.
• W162907728 cites W2135000328 @default.
• W162907728 cites W2135187880 @default.
• W162907728 cites W2145903120 @default.
• W162907728 cites W2149897099 @default.
• W162907728 cites W2150926065 @default.
• W162907728 cites W2153667576 @default.
• W162907728 cites W2155612034 @default.
• W162907728 cites W2155675863 @default.

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