Matches in SemOpenAlex for { <https://semopenalex.org/work/W1629121594> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W1629121594 endingPage "609" @default.
- W1629121594 startingPage "601" @default.
- W1629121594 abstract "Qingkailing (QKL) injection, a modified modern Chinese medicine preparation, is widely used in the clinic for its significant antipyretic and anti-inflammatory effects, but its serious adverse drug reactions have attracted more and more attention. Series of caffeoylquinic acids in QKL are widely suspected to be the allergens responsible for these adverse drug reactions. Therefore, pharmacokinetic studies of the caffeoylquinic acids are needed. In this paper, a simple, rapid and sensitive ultra-performance liquid chromatography–tandem mass spectrometry method was developed for the simultaneous determination of chlorogenic acid, neochlorogenic acid, baicalin, geniposide, cholic acid and hyodeoxycholic acid in rat plasma. Chromatographic separation was achieved on a BEH C18 column by a gradient elution at a flow rate of 0.40 mL/min in only 6.0 min. All analytes were monitored by multiple reaction monitoring mode with negative electrospray ionization. The calibration curves of these analytes were all linear (r > 0.9978) over wide concentration ranges. The intra- and inter- day precisions (relative standard deviations) were within 14.3% and accuracy (relative error) ranged from −6.8 to 4.8%. The mean recoveries ranged from 74.5 to 105.6%. This validated method was successfully applied to the pharmacokinetic study of the six analytes in rats following an intravenous administration of QKL injection. Copyright © 2013 John Wiley & Sons, Ltd." @default.
- W1629121594 created "2016-06-24" @default.
- W1629121594 creator A5002092115 @default.
- W1629121594 creator A5014303029 @default.
- W1629121594 creator A5028385640 @default.
- W1629121594 creator A5037146133 @default.
- W1629121594 creator A5038034103 @default.
- W1629121594 creator A5051418279 @default.
- W1629121594 creator A5066716873 @default.
- W1629121594 creator A5068215482 @default.
- W1629121594 date "2013-11-04" @default.
- W1629121594 modified "2023-10-16" @default.
- W1629121594 title "A rapid and sensitive UPLC-MS/MS method for quantification of two caffeoylquinic acids and four main active components in rat plasma after an intravenous administration of Qingkailing injection and its application to a pharmacokinetic study" @default.
- W1629121594 cites W1969157605 @default.
- W1629121594 cites W1986941645 @default.
- W1629121594 cites W1987830693 @default.
- W1629121594 cites W1989035333 @default.
- W1629121594 cites W1995429872 @default.
- W1629121594 cites W1995976832 @default.
- W1629121594 cites W2001574197 @default.
- W1629121594 cites W2005634130 @default.
- W1629121594 cites W2012840245 @default.
- W1629121594 cites W2021754818 @default.
- W1629121594 cites W2039811147 @default.
- W1629121594 cites W2042172323 @default.
- W1629121594 cites W2055490374 @default.
- W1629121594 cites W2081706995 @default.
- W1629121594 cites W2121129723 @default.
- W1629121594 doi "https://doi.org/10.1002/bmc.3077" @default.
- W1629121594 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24185835" @default.
- W1629121594 hasPublicationYear "2013" @default.
- W1629121594 type Work @default.
- W1629121594 sameAs 1629121594 @default.
- W1629121594 citedByCount "17" @default.
- W1629121594 countsByYear W16291215942014 @default.
- W1629121594 countsByYear W16291215942015 @default.
- W1629121594 countsByYear W16291215942016 @default.
- W1629121594 countsByYear W16291215942017 @default.
- W1629121594 countsByYear W16291215942018 @default.
- W1629121594 countsByYear W16291215942019 @default.
- W1629121594 countsByYear W16291215942020 @default.
- W1629121594 countsByYear W16291215942021 @default.
- W1629121594 countsByYear W16291215942022 @default.
- W1629121594 crossrefType "journal-article" @default.
- W1629121594 hasAuthorship W1629121594A5002092115 @default.
- W1629121594 hasAuthorship W1629121594A5014303029 @default.
- W1629121594 hasAuthorship W1629121594A5028385640 @default.
- W1629121594 hasAuthorship W1629121594A5037146133 @default.
- W1629121594 hasAuthorship W1629121594A5038034103 @default.
- W1629121594 hasAuthorship W1629121594A5051418279 @default.
- W1629121594 hasAuthorship W1629121594A5066716873 @default.
- W1629121594 hasAuthorship W1629121594A5068215482 @default.
- W1629121594 hasConcept C10390740 @default.
- W1629121594 hasConcept C112705442 @default.
- W1629121594 hasConcept C119128265 @default.
- W1629121594 hasConcept C162356407 @default.
- W1629121594 hasConcept C185592680 @default.
- W1629121594 hasConcept C23531484 @default.
- W1629121594 hasConcept C2780117898 @default.
- W1629121594 hasConcept C31827203 @default.
- W1629121594 hasConcept C40684141 @default.
- W1629121594 hasConcept C43617362 @default.
- W1629121594 hasConcept C71043704 @default.
- W1629121594 hasConcept C71924100 @default.
- W1629121594 hasConcept C98274493 @default.
- W1629121594 hasConceptScore W1629121594C10390740 @default.
- W1629121594 hasConceptScore W1629121594C112705442 @default.
- W1629121594 hasConceptScore W1629121594C119128265 @default.
- W1629121594 hasConceptScore W1629121594C162356407 @default.
- W1629121594 hasConceptScore W1629121594C185592680 @default.
- W1629121594 hasConceptScore W1629121594C23531484 @default.
- W1629121594 hasConceptScore W1629121594C2780117898 @default.
- W1629121594 hasConceptScore W1629121594C31827203 @default.
- W1629121594 hasConceptScore W1629121594C40684141 @default.
- W1629121594 hasConceptScore W1629121594C43617362 @default.
- W1629121594 hasConceptScore W1629121594C71043704 @default.
- W1629121594 hasConceptScore W1629121594C71924100 @default.
- W1629121594 hasConceptScore W1629121594C98274493 @default.
- W1629121594 hasIssue "5" @default.
- W1629121594 hasLocation W16291215941 @default.
- W1629121594 hasLocation W16291215942 @default.
- W1629121594 hasOpenAccess W1629121594 @default.
- W1629121594 hasPrimaryLocation W16291215941 @default.
- W1629121594 hasRelatedWork W1989080374 @default.
- W1629121594 hasRelatedWork W2012075101 @default.
- W1629121594 hasRelatedWork W2014605936 @default.
- W1629121594 hasRelatedWork W2026409371 @default.
- W1629121594 hasRelatedWork W2035321010 @default.
- W1629121594 hasRelatedWork W2044145238 @default.
- W1629121594 hasRelatedWork W2074280965 @default.
- W1629121594 hasRelatedWork W2352932869 @default.
- W1629121594 hasRelatedWork W2612271203 @default.
- W1629121594 hasRelatedWork W2912941392 @default.
- W1629121594 hasVolume "28" @default.
- W1629121594 isParatext "false" @default.
- W1629121594 isRetracted "false" @default.
- W1629121594 magId "1629121594" @default.
- W1629121594 workType "article" @default.