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• W1629565836 abstract "Fumaria capreolata is used in traditional medicine in North Africa for its gastrointestinal and anti-inflammatory activities. The present study investigates the effects of total alkaloids extracted from the aerial parts of Fumaria capreolata (AFC) on LPS-induced production of proinflammatory mediators (IL-6, IL-1β, iNOS, TNF-α, COX-2, and MIP-2) in RAW264.7 cells. AFC significantly reduced the inflammatory response inhibiting the production of nitric oxide (NO) and IL-6 in a dose-dependent manner, without affecting the viability of cells, and downregulated mRNA expression of proinflammatory key players: IL-6, IL-1β, iNOS, TNF-α, and COX-2. AFC antinociceptive and anti-inflammatory properties were also evaluated on the acetic acid- and formalin-induced pain models in mice. AFC oral administration significantly inhibited acetic acid-induced writhes and reduced formalin-induced paw licking time. Therefore, AFC may be a potential candidate for the treatment of inflammatory diseases, such as colitis and arthritis." @default.
• W1629565836 created "2016-06-24" @default.
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• W1629565836 date "2015-01-01" @default.
• W1629565836 modified "2023-10-15" @default.
• W1629565836 title "Antinociceptive and Anti-Inflammatory Effects of Total Alkaloid Extract from<i>Fumaria capreolata</i>" @default.
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• W1629565836 doi "https://doi.org/10.1155/2015/736895" @default.
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