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• W1629876601 abstract "Abstract The generation of pigs devoid of Galα1,3Galβ1,4GlcNAc (Gal) residues has stimulated interest in non-Gal Ags as potentially important targets for Ab binding leading to rejection of pig organ xenografts in humans. Although N-glycolylneuraminic acid (NeuGc) epitopes, which are widely expressed on the endothelial cells of all mammals except humans, are likely targets of anti–non-Gal Abs, this aspect has not been investigated intensively owing to the absence of an appropriate animal model. In this study, we used CMAH−/− mice, which are completely deficient in NeuGc and thus produce anti-NeuGc Abs. Sera obtained from CMAH−/− mice and healthy human volunteers having anti-NeuGc Abs initiated complement-mediated lysis against CMAH+/+ cells in vitro. The cytotoxic activity of anti-NeuGc Abs was also determined in vivo (i.e., NeuGc-expressing CMAH+/+ mouse splenocytes that had been i.v. injected were completely eliminated in syngeneic CMAH−/− mice). CMAH−/− mice rejected the islets transplanted from syngeneic CMAH+/+ mice. Thus, the anti-NeuGc Ab-mediated response may be crucially involved in xenograft loss. This is the first direct demonstration of the immunogenic property of NeuGc determinants as targets of the corresponding Abs in CMAH+/+-to-CMAH−/− transplantation setting." @default.
• W1629876601 created "2016-06-24" @default.
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• W1629876601 date "2010-03-15" @default.
• W1629876601 modified "2023-10-03" @default.
• W1629876601 title "Immunological Property of Antibodies against <i>N</i>-Glycolylneuraminic Acid Epitopes in Cytidine Monophospho–<i>N</i>-Acetylneuraminic Acid Hydroxylase-Deficient Mice" @default.
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• W1629876601 doi "https://doi.org/10.4049/jimmunol.0902857" @default.
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• W1629876601 hasPublicationYear "2010" @default.
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