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- W1630196616 abstract "Previous work from our laboratory has shown that the melanocortin system is required for the acute homeostatic responses to increased dietary fat (Butler et al., 2001). In this study we examine the mechanism underlying the energy expenditure defect observed in melanocortin-4 receptor null (MC4R-/-) mice. Using specific polysynaptic retrograde tracing from interscapular brown adipose tissue (IBA T) coupled with dual labeling immunohistochemistry, we show co-expression of MC4R-green fluorescent proteinimmunoreactivity (MC4R-GFP-IR) and the attenuated pseudorabies virus (PRV)-IR in many hypothalamic and brain stem regions known to play an important role in nonshivering thermogenesis, demonstrating an anatomical link between the central melanocortin system and the sympathetically-mediated regulation of IBA T thermogenic function. Additionally, using both genetic and pharmacological antagonism, we show that intact MC4R signaling is required to appropriately up-regulate UCPl in response to physiological stimuli, such as a high-fat diet and short-term cold exposure. Our results that MC4R-/and agouti related peptide (AGRP)-treated mice on a high-fat diet have a similar increase in their total serum 3,5,3 '-triiodothyronine (T,) levels to wild-type controls also suggests that the MC4R-mediated up-regulation of UCPl in response to a > high-fat diet is independent of the central hypothalamic-pituitary-thyroid (HPT) axis. Our data showing that UCPl is up-regulated normally in MC4R-/mice after longer periods of cold exposure suggests that melanocortin system-mediated non-shivering thermogenesis may be differentially regulated by diet and cold or alternatively that compensatory mechanisms may develop in these animals after long-term cold exposure." @default.
- W1630196616 created "2016-06-24" @default.
- W1630196616 creator A5044738045 @default.
- W1630196616 date "2006-01-01" @default.
- W1630196616 modified "2023-09-23" @default.
- W1630196616 title "Examining the role of the central melanocortin system in the regulation of adaptive thermogenesis of brown adipose tissu" @default.
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