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- W1630210887 abstract "Objectives To determine whether recent technical modifications have improved clinical outcomes for patients undergoing contemporary bifurcation lesion percutaneous coronary intervention (PCI). Background Provisional side branch (SB)‐stenting has become the preferred strategy for bifurcation PCI. Newer generation drug‐eluting stents (DESs), the proximal optimization technique (POT), and the use of noncompliant (NC) balloons for final kissing inflation (FKI) have the potential to optimize outcomes. Method We compared baseline characteristics, procedural and clinical outcomes in 300 consecutive patient pairs treated in 2005 and 2009. The primary outcome measure was the cumulative incidence of major adverse cardiac events (MACE) at 2‐years. Results Compared to 2005, patients undergoing PCI in 2009 were at higher risk: prior myocardial infarction (18% vs. 8%, P = 0.0004), left ventricular function (EF 54 ± 13% vs. 61 ± 12%, P < 0.0001). Cypher (53 vs. 3%, P < 0.001) and Taxus (47 vs. 11%, P < 0.0001) stents were used more frequently in 2005, and Xience V in 2009 (0 vs. 47%, P < 0.0001). In 2009, the POT was performed in 36% and NC balloons used for FKI in 81%. SB stenting was required less frequently in 2009 (9% vs. 22%, P < 0.001). Two‐year MACE was significantly lower in 2009 than 2005 (5.7 vs. 11.3%, P = 0.02), a difference driven by fewer cardiac deaths (2.0 vs. 5.0%, P = 0.05). MACE was independently associated with left main bifurcation treatment [hazard ratio (HR) 1.85:95%, CI 1.04–3.29; P = 0.036], side‐branch stenting (HR 2.31:95% CI 1.27–4.20; P = 0.006), and PCI in 2005 (HR 1.86:95% CI 1.03–3.37; P = 0.004). Conclusions Together, contemporary techniques and newer generation DES appear to improve outcomes and are both recommended for widespread uptake in patients undergoing provisional SB stenting for coronary bifurcation lesions.© 2013 Wiley Periodicals, Inc." @default.
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- W1630210887 date "2013-03-25" @default.
- W1630210887 modified "2023-10-10" @default.
- W1630210887 title "Provisional side branch-stenting for coronary bifurcation lesions" @default.
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- W1630210887 doi "https://doi.org/10.1002/ccd.24901" @default.
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