FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1630341904> ?p ?o ?g. }

• W1630341904 endingPage "5773" @default.
• W1630341904 startingPage "5765" @default.
• W1630341904 abstract "Abstract The combined presence of anti-phospholipid Ab (aPL) and thrombosis is recognized as the antiphospholipid syndrome (APS). The aPL represent a heterogeneous group of Ab that recognize various phospholipids (PL), PL-binding plasma proteins, and/or PL-protein complexes. Recently, we found the presence of antithrombin Ab in some APS patients and that some of these anti-thrombin Ab could inhibit thrombin inactivation by antithrombin. Considering that thrombin is homologous to plasmin, which dissolves fibrin, we hypothesize that some APS patients may have Ab that react with plasmin, and that some anti-plasmin Ab may interfere with the plasmin-mediated lysis of fibrin clots. To test this hypothesis, we searched for anti-plasmin Ab in APS patients and then studied those found for their effects on the fibrinolytic pathway. The results revealed that seven of 25 (28%) APS patients have IgG anti-plasmin Ab (using the mean OD plus 3 SD of 20 normal controls as the cutoff) and that six of six patient-derived IgG anti–thrombin mAb bind to plasmin with relative Kd values ranging from 5.6 × 10−8 to 1 × 10−6 M. These Kd values probably represent affinities in the higher ranges known for human IgG autoantibodies against protein autoantigens. Of these mAb, one could reduce the plasmin-mediated lysis of fibrin clots. These findings suggest that plasmin may be an important driving Ag for some aPL B cells in APS patients, and that the induced anti-plasmin Ab may act either directly, by binding to plasmin and inhibiting its fibrinolytic activity, or indirectly, by cross-reacting with other homologous proteins in the coagulation cascade to promote thrombosis." @default.
• W1630341904 created "2016-06-24" @default.
• W1630341904 creator A5004958903 @default.
• W1630341904 creator A5016011317 @default.
• W1630341904 creator A5019377662 @default.
• W1630341904 creator A5024094148 @default.
• W1630341904 creator A5032907771 @default.
• W1630341904 creator A5038110206 @default.
• W1630341904 creator A5061983996 @default.
• W1630341904 creator A5072870816 @default.
• W1630341904 date "2004-05-01" @default.
• W1630341904 modified "2023-10-11" @default.
• W1630341904 title "Identification of Anti-Plasmin Antibodies in the Antiphospholipid Syndrome That Inhibit Degradation of Fibrin" @default.
• W1630341904 cites W117549667 @default.
• W1630341904 cites W1486883909 @default.
• W1630341904 cites W1495740329 @default.
• W1630341904 cites W1530430498 @default.
• W1630341904 cites W1596313173 @default.
• W1630341904 cites W1975548837 @default.
• W1630341904 cites W1983410783 @default.
• W1630341904 cites W1985944570 @default.
• W1630341904 cites W1986703193 @default.
• W1630341904 cites W1991206763 @default.
• W1630341904 cites W1991721757 @default.
• W1630341904 cites W1993393605 @default.
• W1630341904 cites W1994384381 @default.
• W1630341904 cites W1994773511 @default.
• W1630341904 cites W2000055469 @default.
• W1630341904 cites W2009310436 @default.
• W1630341904 cites W2010034007 @default.
• W1630341904 cites W2012076921 @default.
• W1630341904 cites W2030575994 @default.
• W1630341904 cites W2037492035 @default.
• W1630341904 cites W2046147253 @default.
• W1630341904 cites W2056841344 @default.
• W1630341904 cites W2062076668 @default.
• W1630341904 cites W2078129398 @default.
• W1630341904 cites W2079845152 @default.
• W1630341904 cites W2081418701 @default.
• W1630341904 cites W2088071042 @default.
• W1630341904 cites W2101831374 @default.
• W1630341904 cites W2113891001 @default.
• W1630341904 cites W2129149737 @default.
• W1630341904 cites W2148404862 @default.
• W1630341904 cites W2256255199 @default.
• W1630341904 cites W2415371444 @default.
• W1630341904 cites W2417963531 @default.
• W1630341904 cites W4231541477 @default.
• W1630341904 cites W4250512610 @default.
• W1630341904 cites W6001644 @default.
• W1630341904 doi "https://doi.org/10.4049/jimmunol.172.9.5765" @default.
• W1630341904 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15100323" @default.
• W1630341904 hasPublicationYear "2004" @default.
• W1630341904 type Work @default.
• W1630341904 sameAs 1630341904 @default.
• W1630341904 citedByCount "73" @default.
• W1630341904 countsByYear W16303419042012 @default.
• W1630341904 countsByYear W16303419042013 @default.
• W1630341904 countsByYear W16303419042014 @default.
• W1630341904 countsByYear W16303419042015 @default.
• W1630341904 countsByYear W16303419042016 @default.
• W1630341904 countsByYear W16303419042017 @default.
• W1630341904 countsByYear W16303419042018 @default.
• W1630341904 countsByYear W16303419042019 @default.
• W1630341904 countsByYear W16303419042020 @default.
• W1630341904 countsByYear W16303419042021 @default.
• W1630341904 countsByYear W16303419042022 @default.
• W1630341904 countsByYear W16303419042023 @default.
• W1630341904 crossrefType "journal-article" @default.
• W1630341904 hasAuthorship W1630341904A5004958903 @default.
• W1630341904 hasAuthorship W1630341904A5016011317 @default.
• W1630341904 hasAuthorship W1630341904A5019377662 @default.
• W1630341904 hasAuthorship W1630341904A5024094148 @default.
• W1630341904 hasAuthorship W1630341904A5032907771 @default.
• W1630341904 hasAuthorship W1630341904A5038110206 @default.
• W1630341904 hasAuthorship W1630341904A5061983996 @default.
• W1630341904 hasAuthorship W1630341904A5072870816 @default.
• W1630341904 hasBestOaLocation W16303419041 @default.
• W1630341904 hasConcept C126322002 @default.
• W1630341904 hasConcept C153911025 @default.
• W1630341904 hasConcept C159654299 @default.
• W1630341904 hasConcept C163764329 @default.
• W1630341904 hasConcept C181199279 @default.
• W1630341904 hasConcept C185592680 @default.
• W1630341904 hasConcept C203014093 @default.
• W1630341904 hasConcept C2776825266 @default.
• W1630341904 hasConcept C2776874634 @default.
• W1630341904 hasConcept C2777292125 @default.
• W1630341904 hasConcept C2777557582 @default.
• W1630341904 hasConcept C2779026020 @default.
• W1630341904 hasConcept C2781071845 @default.
• W1630341904 hasConcept C54173615 @default.
• W1630341904 hasConcept C55493867 @default.
• W1630341904 hasConcept C71924100 @default.
• W1630341904 hasConcept C86803240 @default.
• W1630341904 hasConcept C89560881 @default.
• W1630341904 hasConceptScore W1630341904C126322002 @default.
• W1630341904 hasConceptScore W1630341904C153911025 @default.

• next