Matches in SemOpenAlex for { <https://semopenalex.org/work/W1630438399> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W1630438399 endingPage "203.41" @default.
- W1630438399 startingPage "203.41" @default.
- W1630438399 abstract "Abstract STAT6 signaling pathway has important pathophysiologic implications in a variety of cell types and diseases. On cancer studies, mice lacking STAT6 display enhanced tumor immunity to both primary and metastatic mammary carcinomas. In humans, STAT6 protein has been found to be constitutively activated in several cancer types. However, the role of STAT6 in influencing the resistance or susceptibility of colon cancer cells to apoptosis and invasiveness/metastasis has not yet been validated during in vivo colitis-associated colon cancer (CAC).This study aims to identify the effects of STAT6 in tumorigenesis utilizing STAT6-KO mice in an experimental CAC model and evaluating changes in immune cell populations in the absence of this gene. CAC was induced in both STAT6-KO and WT mice by injection of 12.5 mg/kg AOM followed by three rounds of 2% DSS exposure to elicit colitis. On day 63 after CAC induction, mice were sacrificed. Colonic inflammation, proliferation and tumorigenesis were evaluated. Tumor numbers per mouse (0.8 versus 19.6; P=0.0001), and bowel weight (0.3 versus 0.6 g; P=0.05) were significantly decreased in STAT6-KO mice compared to WT mice. Furthermore, both inflammation and proliferation scores in colon from STAT6-KO mice were significantly lower than WT mice. Although additional studies are needed to clarify the mechanism(s) underlying improved anti-tumor immunity in STAT6-KO mice, these results may be a basis for an immunotherapy strategy in CAC development." @default.
- W1630438399 created "2016-06-24" @default.
- W1630438399 creator A5013549809 @default.
- W1630438399 creator A5016681940 @default.
- W1630438399 creator A5029555852 @default.
- W1630438399 creator A5032446560 @default.
- W1630438399 creator A5051238736 @default.
- W1630438399 creator A5055599650 @default.
- W1630438399 creator A5063510856 @default.
- W1630438399 creator A5071791824 @default.
- W1630438399 creator A5081606791 @default.
- W1630438399 creator A5088294076 @default.
- W1630438399 creator A5091096815 @default.
- W1630438399 date "2014-05-01" @default.
- W1630438399 modified "2023-10-17" @default.
- W1630438399 title "Role of signal transducer and activator of transcription 6 in the development of colitis associated colorectal cancer (TUM7P.959)" @default.
- W1630438399 doi "https://doi.org/10.4049/jimmunol.192.supp.203.41" @default.
- W1630438399 hasPublicationYear "2014" @default.
- W1630438399 type Work @default.
- W1630438399 sameAs 1630438399 @default.
- W1630438399 citedByCount "0" @default.
- W1630438399 crossrefType "journal-article" @default.
- W1630438399 hasAuthorship W1630438399A5013549809 @default.
- W1630438399 hasAuthorship W1630438399A5016681940 @default.
- W1630438399 hasAuthorship W1630438399A5029555852 @default.
- W1630438399 hasAuthorship W1630438399A5032446560 @default.
- W1630438399 hasAuthorship W1630438399A5051238736 @default.
- W1630438399 hasAuthorship W1630438399A5055599650 @default.
- W1630438399 hasAuthorship W1630438399A5063510856 @default.
- W1630438399 hasAuthorship W1630438399A5071791824 @default.
- W1630438399 hasAuthorship W1630438399A5081606791 @default.
- W1630438399 hasAuthorship W1630438399A5088294076 @default.
- W1630438399 hasAuthorship W1630438399A5091096815 @default.
- W1630438399 hasConcept C121608353 @default.
- W1630438399 hasConcept C126322002 @default.
- W1630438399 hasConcept C145430368 @default.
- W1630438399 hasConcept C171958077 @default.
- W1630438399 hasConcept C190283241 @default.
- W1630438399 hasConcept C191732599 @default.
- W1630438399 hasConcept C203014093 @default.
- W1630438399 hasConcept C2775862500 @default.
- W1630438399 hasConcept C2776914184 @default.
- W1630438399 hasConcept C2778923194 @default.
- W1630438399 hasConcept C2779013556 @default.
- W1630438399 hasConcept C2779341262 @default.
- W1630438399 hasConcept C502942594 @default.
- W1630438399 hasConcept C526805850 @default.
- W1630438399 hasConcept C55493867 @default.
- W1630438399 hasConcept C555283112 @default.
- W1630438399 hasConcept C71924100 @default.
- W1630438399 hasConcept C86803240 @default.
- W1630438399 hasConcept C8891405 @default.
- W1630438399 hasConceptScore W1630438399C121608353 @default.
- W1630438399 hasConceptScore W1630438399C126322002 @default.
- W1630438399 hasConceptScore W1630438399C145430368 @default.
- W1630438399 hasConceptScore W1630438399C171958077 @default.
- W1630438399 hasConceptScore W1630438399C190283241 @default.
- W1630438399 hasConceptScore W1630438399C191732599 @default.
- W1630438399 hasConceptScore W1630438399C203014093 @default.
- W1630438399 hasConceptScore W1630438399C2775862500 @default.
- W1630438399 hasConceptScore W1630438399C2776914184 @default.
- W1630438399 hasConceptScore W1630438399C2778923194 @default.
- W1630438399 hasConceptScore W1630438399C2779013556 @default.
- W1630438399 hasConceptScore W1630438399C2779341262 @default.
- W1630438399 hasConceptScore W1630438399C502942594 @default.
- W1630438399 hasConceptScore W1630438399C526805850 @default.
- W1630438399 hasConceptScore W1630438399C55493867 @default.
- W1630438399 hasConceptScore W1630438399C555283112 @default.
- W1630438399 hasConceptScore W1630438399C71924100 @default.
- W1630438399 hasConceptScore W1630438399C86803240 @default.
- W1630438399 hasConceptScore W1630438399C8891405 @default.
- W1630438399 hasIssue "1_Supplement" @default.
- W1630438399 hasLocation W16304383991 @default.
- W1630438399 hasOpenAccess W1630438399 @default.
- W1630438399 hasPrimaryLocation W16304383991 @default.
- W1630438399 hasRelatedWork W1499339123 @default.
- W1630438399 hasRelatedWork W1557621914 @default.
- W1630438399 hasRelatedWork W1630438399 @default.
- W1630438399 hasRelatedWork W172997010 @default.
- W1630438399 hasRelatedWork W1926962973 @default.
- W1630438399 hasRelatedWork W2014350403 @default.
- W1630438399 hasRelatedWork W2415460278 @default.
- W1630438399 hasRelatedWork W2896666172 @default.
- W1630438399 hasRelatedWork W2900031363 @default.
- W1630438399 hasRelatedWork W4206107686 @default.
- W1630438399 hasVolume "192" @default.
- W1630438399 isParatext "false" @default.
- W1630438399 isRetracted "false" @default.
- W1630438399 magId "1630438399" @default.
- W1630438399 workType "article" @default.