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- W1630688669 abstract "Abstract Purified peripheral blood T lymphocytes from normal donors were shown to help allogeneic tonsillar B cells to differentiate and secrete specific anti-SRBC antibody in vitro in a plaque-forming assay. Utilizing this system, a comparison was made between the allogeneic helper activity generated by the T cells of normal individuals and patients with various disease states. Allogeneic helper activity was absent when T lymphocytes from patients with CLL were used. Conversely, relatively normal allogeneic helper function was provided by T cells of patients with a variety of other disorders studied. Thus, a functional deficiency was identified in CLL patients in the subpopulation of regulatory T cells responsible for providing helper activity in allogeneic interactions." @default.
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- W1630688669 date "1979-03-01" @default.
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- W1630688669 title "T Cell Helper Defect in Patients with Chronic Lymphocytic Leukemia" @default.
- W1630688669 doi "https://doi.org/10.4049/jimmunol.122.3.1087" @default.
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