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• W1630763432 abstract "The products of the shc gene appear to be substrates for activated oncogenic tyrosine kinases, such as v-Src and v-Fps and activated tyrosine kinase receptors like the epidermal growth factor (EGF) and platelet-derived growth factor (PDGF) receptors. We investigated whether the Shc proteins are targets for the activated insulin receptor tyrosine kinase. Here we show that the 46- and 52-kDa Shc proteins are rapidly phosphorylated upon insulin receptor activation in fibroblasts expressing elevated levels of human insulin receptors. Furthermore, we observed insulin-induced association of a 23-kDa protein with the Shc proteins. These effects on Shc proteins are similar to those observed after EGF and PDGF treatment. In contrast to the observed Shc-EGF receptor association, we did not detect association between the Shc proteins and the insulin receptor. We conclude that the Shc proteins are common elements in a signal transduction pathway that is shared by EGF, PDGF, and insulin." @default.
• W1630763432 created "2016-06-24" @default.
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• W1630763432 date "1993-03-01" @default.
• W1630763432 modified "2023-09-27" @default.
• W1630763432 title "Insulin-induced phosphorylation of the 46- and 52-kDa Shc proteins." @default.
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• W1630763432 doi "https://doi.org/10.1016/s0021-9258(18)53382-2" @default.
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