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- W1630881925 endingPage "97" @default.
- W1630881925 startingPage "97" @default.
- W1630881925 abstract "Metabolomics has increasingly been applied in addition to other omic approaches in the study of the pathophysiology of different gastrointestinal diseases. Metabolites represent molecular readouts of the cell status reflecting a physiological phenotype. In addition, changes in metabolite concentrations induced by exogenous factors such as environmental and dietary factors which do not affect the genome, are taken into account. Metabolic reactions initiated by the host or gut microbiota can lead to marker metabolites present in different biological fluids that allow differentiation between health and disease. Several lines of evidence implicated the involvement of intestinal microbiota in the pathogenesis of inflammatory bowel disease (IBD). Also in irritable bowel syndrome (IBS), a role of an abnormal microbiota composition, so-called dysbiosis, is supported by experimental data. These compositional alterations could play a role in the aetiology of both diseases by altering the metabolic activities of the gut bacteria. Several studies have applied a metabolomic approach to identify these metabolite signatures. However, before translating a potential metabolite biomarker into clinical use, additional validation studies are required. This review summarizes contributions that metabolomics has made in IBD and IBS and presents potential future directions within the field." @default.
- W1630881925 created "2016-06-24" @default.
- W1630881925 creator A5042026584 @default.
- W1630881925 creator A5047410548 @default.
- W1630881925 date "2013-01-01" @default.
- W1630881925 modified "2023-09-26" @default.
- W1630881925 title "Metabolomics as a diagnostic tool in gastroenterology" @default.
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- W1630881925 doi "https://doi.org/10.4292/wjgpt.v4.i4.97" @default.
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