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- W1631061798 abstract "Las celulas malignas deben adquirir un potencial de replicacion ilimitado (inmortalidad celular) para la formacion de tumores avanzados. La adquisicion de inmortalidad celular depende de la reactivacion de la telomerasa, una enzima que permite compensar el problema de replicacion terminal del ADN asociado a cada division celular. En una serie de estudios presentados en esta tesis, se demuestra:1. La telomerasa es una enzima regulable en celulas tumorales humanas.2. Los tumores humanos expresan actividad telomerasa y su expresion se asocia a estadio tumoral, indice proliferativo y diferenciacion3. La telomerasa es una diana antitumoral atractiva.Malignant cells have to acquire a limitless replicative potential (immortality) to be able to form an advanced tumor. The acquisition of cellular imortality is linked to the reactivation of telomerase, an enzyme that has the potential to overcome the DNA end replication problem that occurs during each round of cell division. In a series of studies presented in this thesis, it has been shown:1. Telomerase is a regulable enzyme in human tumor cells.2. Human tumors express telomerase activity and this expresion is asociate to tumor stage, proliferative index and maturation.3. Telomerase is an attractive anticancer targe._" @default.
- W1631061798 created "2016-06-24" @default.
- W1631061798 creator A5022866417 @default.
- W1631061798 date "2001-04-03" @default.
- W1631061798 modified "2023-09-28" @default.
- W1631061798 title "Telomerasa: regulación, diana terapéutica y significado clínico en neoplasias humanas" @default.
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