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• W1631094551 abstract "Rapid damage to the cells was observed when a macrophage-like cell line, J774.1, was incubated with LPS in the presence of cycloheximide (CHI). Cells of an LPS-sensitive subline of J774.1, JA-4, but not an LPS-resistant mutant, LPS1916, became swollen and detached from the culture dish on treatment with 10 ng/ml LPS and 10 μg/ml CHI at 37°C for 4 h, accompanied with the release of lactate dehydrogenase. These changes were dependent on both LPS and CHI, and the addition of CHI to the macrophages later than 1 h after the addition of LPS failed to induce the cytotoxicity. As for the mechanism, protein kinase C (PKC) seemed to be involved, because down-regulation of PKC and staurosporine reduced the cytotoxicity. The cytotoxicity was dependent on serum, suggesting the involvement of CD14/LPS binding protein. However, TNFα does not seem to participate, because an anti-TNFα antibody did not inhibit the cytotoxicity and TNFα could not replace LPS." @default.
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• W1631094551 date "1996-10-01" @default.
• W1631094551 modified "2023-09-27" @default.
• W1631094551 title "A cytotoxic effect of lipopolysaccharide on a macrophage-like cell line, J774.1, in the presence of cycloheximide" @default.
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• W1631094551 doi "https://doi.org/10.1177/096805199600300505" @default.
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