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• W1631622412 abstract "This chapter discusses the transgenic models for bone disease. Genetically manipulated mice are used extensively for the study of the function of a wide variety of eukaryotic genes in an intact organism. The genetically-manipulated mouse also provides a means of creating models of human disease, thus increasing our understanding of normal physiology as well as pathophysiology of several important human diseases. Two sorts of genetic manipulations are normally carried out. One of these, the classical “transgenic,” involves the overexpression of the gene of interest in a mouse. In essence, this approach provides for a useful model to study the function and regulation of a particular gene in a tissue-specific manner. In this technique, recombinant DNA molecules are introduced by microinjection into pronuclei of fertilized mouse eggs. The transgene, in most instances, is randomly integrated into the genome, and is then transmitted in the germline. The other more recent approach, popularly termed the “knockout mouse” or gene targeting, is based on the inactivation of a specific gene through its targeted disruption. This model provides information on whether a gene product is required for the specific function that has been previously attributed to the gene, as well as to identify its novel functions. It is a particularly powerful tool in evaluating the function of a gene product during embryonic development. Both techniques have provided vital insights into skeletal development, as well as in understanding the pathophysiology of important bone and mineral disorders. Depending upon the time point in embryonic or fetal development at which a specific gene is expressed, its effects on the resulting phenotype can be varied." @default.
• W1631622412 created "2016-06-24" @default.
• W1631622412 creator A5021379552 @default.
• W1631622412 date "1998-01-01" @default.
• W1631622412 modified "2023-09-26" @default.
• W1631622412 title "Transgenic Models for Bone Disease" @default.
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• W1631622412 cites W1820036906 @default.
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• W1631622412 cites W1977687670 @default.
• W1631622412 cites W1983237714 @default.
• W1631622412 cites W1993064864 @default.
• W1631622412 cites W2000170431 @default.
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• W1631622412 doi "https://doi.org/10.1016/s1569-2590(08)60156-1" @default.
• W1631622412 hasPublicationYear "1998" @default.
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